Objective. To study the levels of some cytokines (IL-6, TNF-α) and endogenous antimicrobial peptides (zonulin, calprotectin and lactoferrin) in patients, suffering hepatic echinococcosis, and to follow-up their changes in dynamics of postoperative treatment. Materials and methods. There were examined 29 patients, ageing 35 - 65 yrs old, operated for hepatic echinococcosis. In accordance to scheme of the treatment conducted after laparoscopic echinococcectomy the patients were distributed into two Groups: the first one - 13 patients, who obtained the standard treatment, and the second - 16 patients, to whom, besides the standard treatment, preparation for immunocorrection was prescribed. Antibodies towards the echinococcus IgG, concentration of endogenous antimicrobal peptides and cytokines in the blood serum were studied, using immuno-enzymal analysis in dynamics. Results. There was established, that in preoperative period in patients, suffering hepatic echinococcosis, high levels of the studied inflammation mediators are revealed, comparing with the indices in healthy persons. Conduction of postoperative treatment promotes a staged lowering of the antimicrobal peptides and cytokines concentrations. Standard treatment is less effective in lowering of the inflammation mediators levels, than combination of conventional treatment with immunocorrection. Conclusion. In the patients, suffering hepatic echinococcosis, the levels of cytokines and antimicrobal peptides are raised. Combined treatment with immunocorrection after echinococcusectomy leads to significant lowering of the inflammation mediators levels.

Objective. To study the cytokines and antimicrobial peptides concentrations in patients with cholelitiasis during 1 year treatment before and after the surgery. Materials and methods. 38 patients with a cholelithiasis were examined and operated in the Educational-Surgical Clinic of the Azerbaijan Medical University. According to the treatment regimen after the operation the patients were divided into two groups: patients of the 1st group (n = 17) received standard treatment; patients of 2nd group (n = 21), in addition to standard treatment hepatoprotectors, combined enzyme preparations, pre- and probiotics were prescribed. The control group consisted of 14 apparently healthy individuals. The levels of inflammatory cytokines (interleukin-6 and tumor necrosis factor-α) in the blood and antimicrobial peptides (zonulin, calprotectin, and lactoferrin) in feces we studied with enzyme immunoassay method. Results. In patients with cholelithiasis of the 1st group, the concentration of interleukin-6 was significantly increased by 5 times (p <0.001), the concentration of tumor necrosis factor-α - by 3.5 times (p <0.001), of zonulin - by 2.2 times (p = 0.012), of calprotectin - by 5.8 times (p <0.001, the concentration of lactoferrin - by 60 times (p <0.001), and in the 2nd group - by 4.8 times (p <0.001), by 3.1 times (p <0.001), on 91.7% (p = 0.011), by 5.8 times (p <0.001) and by 52.8 times (p <0.001) respectively in comparison with the control. Conclusions. Standard postoperative treatment supplemented by hepatoprotectors, combined enzyme preparations, pre- and probiotics prescription leads to a positive dynamics of inflammatory mediators concentration and its normalization.