The mutants of novel coronavirus (COVID-19 or SARS-Cov-2) are spreading with different variants across the globe, affecting human health and the economy. Rapid detection and providing timely treatment for the COVID-19 infected is the greater challenge. For fast and cost-effective detection, artificial intelligence (AI) can perform a key role in enhancing chest X-ray images and classifying them as infected/non-infected. However, AI needs huge datasets to train and detect the COVID-19 infection, which may impact the overall system speed. Therefore, Deep Neural Network (DNN) is preferred over standard AI models to speed up the classification with a set of features from the datasets. Further, to have accurate feature extraction, an algorithm that combines Zernike Moment Feature (ZMF) and Gray Level Co-occurrence Matrix Feature (GF) is proposed and implemented. The proposed algorithm uses 36 Zernike Moment features with variance and contrast textures. This helps to detect the COVID-19 infection accurately. Finally, the Region Blocking (RB) approach with an optimum sub-image size (32 × 32) is employed to improve the processing speed up to 2.6 times per image. The performance of this implementation presents an accuracy (A) of 93.4%, sensitivity (Se) of 72.4%, specificity (Sp) of 95%, precision (Pr) of 74.9% and F1-score (F1) of 72.3%. These metrics illustrate that the proposed model can identify the COVID-19 infection with a lesser dataset and improved accuracy up to 1.3 times than state-of-the-art existing models.

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