The findings from this study indicate a novel mechanism by which hyperglycemia may impact trophoblast function, early placentation, and ultimately, pregnancy outcome.

Scope and Purpose of the Guideline Statement of problemThe mean duration of a normal pregnancy, calculated from the 1st day of the last menstrual period, is 280 days or 40 + 0 weeks of gestation (GW).A pregnancy prolonged by more than 14 days, in other words, a pregnancy lasting 294 days or 42 + 0 GW or more, is defined by the WHO and FIGO as prolonged, post-term or post-mature pregnancy. The period between 40 + 0 and 41 + 6 GW is referred to as late-term pregnancy.More than 40 % of all pregnant women give birth after the expected date of delivery. Management of pregnant women with no onset of labor ranges from expectant management consisting only of intensive monitoring of mother and child to induction of labor.

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