Thirty two apparently healthy animals were used in the study with four bucks per group. There were eight groups in all and two stocking densities. The experimental treatment groups were xylazine at 0.01 mg/kg intramuscularly administered (IM), xylazine at 0.015 mg/kg (IM), xylazine at 0.020 mg/kg (IM) and a control none treated group. Each of the treatments had low and high stocking rates respectively. Thus, 16 animals each were experimented upon for the high and low stocking rates. Xylazine was administered prior and midway into the experimental journey. Physiological parameters taken were: respiratory and heart rates, rectal temperature and excitability score. Biochemical parameters analyzed were: alanine aminotransferase (ALT) aspartate amino transferase (AST), glucose, cholesterol, and protein. The electrolytes analyzed were Ca+, Mg++, Na+ K+ and Cl-. Antioxidative stress markers assayed were glutathione transferase, superoxide dismutase, malonyldialdehyde. Full blood count and thyroid hormones [triiodothyronine (T3) and tetraidothyronine (T4)] were also determined using ELISA. The results show there was no significant (P>0.05) changes at all doses except for cholesterol where the dose of (0.015mg/kg) of xylazine produced a significantly (P<0.05) higher value when compared to the control, and the other treated groups. The serum Na+ and Clwere significantly higher in the group treated with 0.01 mg/kg of xylazine (155.51±15.11 and 121.32±36.90 mg/dl) compared to the control. Xylazine at 0.015 mg/kg and 0.02 mg/kg dose caused a reduction in the Cllevels. Xylazine treatment might have improved adaptability in long term transportation.

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Xylazine hydrochloride (Xylazin ® injection, 2% solution contains xylazine hydrochloride 23.33 mg/kg, Indian immunological Ltd., India) is an 2-adrenergic agonist used in animals. It is a potent sedative/hypnotic agent (Hall and Clarke, 1983). Chemically, it is 2(2, 6dimethylphenylamino)-4H-5, 6-dihydro-1, 3-thiamine hydrochloride (Adams, 2001). Xylazine is classified pharmacologically as an effective sedative, analgesic, muscle relaxant, immobilizing and hypnotic agent in domestic animals (Torre and Erausquine, 1988; Ewing, 1990; Adams, 2001). Xylazine is also known to significantly ameliorate the effects induced by stress stimuli (Ali et al., 2006). It does not possess the undesirable side-effects and deficiencies of the phenothiazine-derived tranquilizer (Mohammed and Yelwa, 1993), and xylazine infusion should not be used in horses during transition from isoflurane anaesthesia to recovery (Wagner et al., 2008). As a well-defined breed in Africa, Sokoto red goats are known for quality skin which is in high demand for leather product with a high retail value (Devendra and McLeroy, 1988). Sokoto State is estimated to have 2.46 million goats with Sokoto red goats found virtually in every household within the state (Anonymous, 1992). The objective of this research was to evaluate the sedative effect of xylazine in Sokoto red goats by way of ascertaining the onset of action, duration of action, effect on some clinicophysiological and haematological parameters.

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