Introduction: Ethanolic extracts of Alternanthera sessilis and Moringa oleifera were screened for the presence of different classes of phytochemicals. The phytochemical screening revealed the presence of amino acids, flavonoids, alkaloids, terpenoids, sapponents and steroids.Gout is the type of arthritis that causes painful inflammation and develops due to overproduction of urate. Aim: To analyse the anti gout activities of ethanolic extract of Alternanthera sessilis and moringa oleifera. Materials and Methods: Ethanolic extract of Alternanthera sessilis and Moringa oleifera were prepared as per the standard methods and used for the assessment of preliminary phytochemical screening, antioxidants and anti gout activities. The data were analyzed statistically by a one-way analysis of (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the group. The results with the p< 0.05 level were considered to be statistically significant. Results: Antioxidant and Anti gout potential of the ethanolic extract of Moringa oleifera was found to be significantly more than the ethanolic extract of Alternanthera sessilis. Conclusion: Both the ethanolic extracts exhibited anti gout activity, further studies are needed to validate the herbal extracts as a drug formulation.