ObjectivesTo predict the structure of protein, which dictates the function it performs, a newly designed algorithm is developed which blends the concept of self-organization and the genetic algorithm.MethodsAmong many other approaches, genetic algorithm is found to be a promising cooperative computational method to solve protein structure prediction in a reasonable time. To automate the right choice of parameter values the influence of self-organization is adopted to design a new genetic operator to optimize the process of prediction. Torsion angles, the local structural parameters which define the backbone of protein are considered to encode the chromosome that enhances the quality of the confirmation. Newly designed self-configured genetic operators are used to develop self-organizing genetic algorithm to facilitate the accurate structure prediction.ResultsPeptides are used to gauge the validity of the proposed algorithm. As a result, the structure predicted shows clear improvements in the root mean square deviation on overlapping the native indicates the overall performance of the algorithm. In addition, the Ramachandran plot results implies that the conformations of phi-psi angles in the predicted structure are better as compared to native and also free from steric hindrances.ConclusionsThe proposed algorithm is promising which contributes to the prediction of a native-like structure by eliminating the time constraint and effort demand. In addition, the energy of the predicted structure is minimized to a greater extent, which proves the stability of protein.

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Falope ring migration has not been reported to produce signs and symptoms suggestive of abdominal or pelvic pathologies. Clinical diagnosis is virtually impossible, and radiological investigations appear imminent to rule out common pathologies. A 40-year-old woman developed severe abdominal pain almost 17 years after laparoscopic tubal ligation with Falope ring. Contrast-enhanced computed tomographic (CECT) scan of the abdomen and pelvis revealed a 3.1×2.6 cm lesion in the inframesocolic compartment of mesentery. Patient was conservatively managed with a two-week course of antibiotics and analgesics for the next seven days following which she improved symptomatically. The patient was contacted after six months of index hospitalization, and she was not willing for surgery as she did not develop symptoms during those six months. This presented patient indicates the possibility of delayed Falope ring migration and it may lead to an abdominal pathology which can masquerade several clinical problems.

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