Aim: To study the Demographic trends, Affected Anatomical sites and histopathological analysis of Oral Squamous Cell Carcinoma at a tertiary care Hospital. Methods: The retrospective study was conducted on 100 patients with OSCC, over a period of 6 years form 2016 – 2022. The data collected from the patient includes age, gender, occupation, habits and other risk factors, anatomic site and grade of the tumour. The obtained specimens were graded as well differentiated, moderately differentiated and poorly differentiated as per WHO criteria. The collected data were subjected to statistical analysis and the results were formulated. Results: A total  of  100  histopathologically  verified  cases  of  OSCC  were  included in this study. Majority of the OSCC patients were within 40 – 60 year age group (48%), followed by > 60 years age group (31%), while 12% of the patients were within 31- 45 years and 9% were below 30 years. Out of the 100 cases, 55% were male and 45% were female, with a male to female ratio of 1.2:1. Conclusion: The results of the present study conclude that, OSCC is most commonly associated with middle age groups, predominantly male.