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Background/Aims: Ultrasound elasticity imaging visually represents tissue hardness measurements using high-resolution ultrasound speckle-tracking algorithms. This method has recently been applied in the renal setting to measure arterial compliance in end-stage renal disease (ESRD) and the mechanical properties of transplant kidneys in vivo. Methods: Ultrasound radio-frequency signal measurements were made of the brachial artery in 5 ESRD subjects and 5 healthy controls and renal transplant measurements in 2 subjects, 1 with chronic allograft nephropathy (CAN) and 1 with normal graft function. Results: Maximal brachial artery percent strain measurements for healthy controls were 32.9 ± 10.2% (mean ± SD) and for ESRD subjects maximal percent strains were 4.9 ± 1.8%. Transplant renal cortical strain for the subject with CAN was approximately one third that of the healthy transplant recipient. Conclusion: Ultrasound elasticity imaging offers the potential to noninvasively measure the mechanical properties of structures within the body.

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