Polarimetric X-and C-band measurements by the University of Sheffield ground-based synthetic aperture radar (GB-SAR) indoor system provide three-dimensional images of the scattering processes in wheat canopies, at resolutions of around a wavelength (3-6 cm). The scattering shows a pronounced layered structure, with strong returns from the soil and the flag leaves, and in some cases a second leaf layer. Differential attenuation at horizontal (H) and vertical (V) polarization, due to the predominantly vertical structure of the wheat stems, gives rise to marked effects. At both C and X bands, direct return from the canopy exceeds the soil return at large incidence angles for VV polarization, but is comparable to or less than the soil return in all other cases. At HV, the apparent ground return is probably due to a double-bounce mechanism, and volume scattering is never the dominant term. Direct sensing of the crop canopy is most effective at X band, VV, and large incidence angles, under which conditions the return is dominated by the flag leaf layer. Field measurements with the outdoor GB-SAR system suggest, however, that for sensitivity to biomass and reduced susceptibility to disturbances by rainfall, a two-channel C-band system operating at a medium range of incidence angles is preferred.Index Terms-Agriculture, backscatter modeling, synthetic aperture radar (SAR).

Background High-intensity focused ultrasound (HIFU) is becoming more widely used for non-invasive and minimally invasive ablation of benign and malignant tumors. Recent studies suggest that HIFU can also enhance targeted drug delivery and stimulate an anti-tumor immune response in many tumors. However, targeting of pancreatic and liver tumors using an extracorporeal source is challenging due to the lack of an adequate acoustic window. The development of an endoscopic ultrasound (EUS)-guided HIFU transducer has many potential benefits including improved targeting, decreased energy requirements and decreased potential for injury to intervening structures. Objective To design, develop and test an EUS-guided HIFU transducer for endoscopic applications. Design A pre-clinical, pilot characterization and feasibility study. Setting Academic research center. Patients Studies were performed in an in vivo porcine model. Intervention Thermal ablation of in vivo porcine pancreas and liver was performed with EUS guided focused ultrasound through the gastric tract. Results The transducer successfully created lesions in gel phantoms and ex vivo bovine livers. In vivo studies demonstrated that targeting and creating lesions in the porcine pancreas and liver are feasible. Limitations This is a pre-clinical, single-center feasibility study with a limited number of subjects. Conclusion An EUS-guided HIFU transducer was successfully designed and developed with dimensions that are appropriate for endoscopic use. Feasibility of performing EUS-guided HIFU ablation in vivo has been demonstrated in an in vivo porcine model. Further development of this technology will allow endoscopists to perform precise therapeutic ablation of peri-lumenal lesions without breaching the wall of the gastric tract.

Ultrasound (US) was applied to a targeted canine liver lobe simultaneously with injection of plasmid DNA (pDNA)/microbubble (MB) complexes into a portal vein (PV) segmental branch and occlusion of the inferior vena cava (IVC) to facilitate DNA uptake. By using a 1.1 MHz, 13 mm diameter transducer, a fivefold increase in luciferase activity was obtained at 3.3 MPa peak negative pressure (PNP) in the treated lobe. For more effective treatment of large tissue volumes in canines, a planar unfocused transducer with a large effective beam diameter (52 mm) was specifically constructed. Its apodized dual element configuration greatly reduced the near-field transaxial pressure variations, resulting in a remarkably uniform field of US exposure for the treated tissues. Together with a 15 kW capacity US amplifier, a 692-fold increase of gene expression was achieved at 2.7 MPa. Transaminase and histology analysis indicated minimal tissue damage. These experiments represent an important developmental step toward US-mediated gene delivery in large animals and clinics.

Abstract. The spatial extent and temporal behaviour of quasi-periodic (QP) intensity modulations of 0.5-2 kHz ELF-VLF signals were investigated in a comparative study of data collected at the Antarctic stations of South Pole (L=14), Halley (L=4), and Siple (L=4). Frequently, the waveforms of ELF-VLF signals simultaneously received at each site were identical. Although of similar frequency structure, the waveforms of the accompanying Pc3 magnetic pulsations did not show a one-to-one association. Whereas both are dayside phenomena, QP emissions occur over a smaller range of local times, and have a maximum of occurrence later in the day closer to local noon. QP emissions are identified with the periodic modulation of the electron pitch-angle distribution by the propagation of ULF compressional fast-mode waves through a region. However, contrary to previous ideas, rising-tone emissions do not represent the frequency-time signatures of such waves. In addition to generation close to the equatorial plane, we propose an additional high-latitude source of QP emissions. These emissions are associated with regions of minimum B produced by the dayside compression of the magnetosphere close to the magnetopause. Model magnetic field calculations of these minimum-B regions as a function of magnetic local time and invariant latitude are presented.