After completing this course, the reader will be able to:1. Identify risk factors for kidney failure associated with high-dose MTX therapy.2. Discuss the therapeutic options in patients with delayed MTX elimination.3. Discuss the potential risks and benefits of glucarpidase intervention.Access and take the CME test online and receive 1 AMA PRA Category 1 Credit ™ at CME.TheOncologist.com CME CME Conclusions. Glucarpidase is well tolerated and produces a rapid inactivation of substantial amounts of MTX. However, overall results are still unsatisfactory in adult and elderly patients, suggesting that earlier recognition of delayed MTX elimination and more rapid intervention are needed. The Oncologist
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