SettingsKerala State, India has reported the greatest dual burden of Tuberculosis (TB) and Diabetes Mellitus (DM). Malappuram district in Kerala has monitored and recorded DM status and its control from 2010 under Revised National Tuberculosis Control Program (RNTCP).ObjectivesTo assess, under programme conditions, comprehensiveness of recording DM status among TB cases and the TB treatment outcomes among DM patients (disaggregated by glycemic control) and compare with-non DM patients.DesignThis retrospective record review included 3,116TB patients from April 2010 to September 2011.DM was defined as per international guidelines and TB treatment outcomes were categorized as favourable(cured and treatment completed) and unfavourable(death, default, failure and transfer out). Relative Risk (RR) and 95% confidence intervals(CI) were calculated to assess the risk of unfavourable outcomes.ResultsDM status was recorded in 90% of TB cases and 667 (24%) had DM. 17% of DM patients and 23% of patients with unknown DM status had unfavourable outcomes but this difference was not statistically significant. Unadjusted RR for poor glycemic control or unknown control status for unfavourable outcome were (2.00; 95% CI 0.97–4.13) and (2.14; 95% CI 1.11–4.13).ConclusionThis study could not confirm an adverse association between DM or its control during treatment and the course of response to TB treatment.DM screening in TB cases and recording of DM care needs to be improved to enable more conclusive evidence.

Aim The aim of this report is to present a case of Glanzmann thrombasthenia (GT) with oral manifestations requiring periodontal management along with a discussion of the clinical, hematologic, and molecular level features of the disease. Background GT is a rare hematological disorder with oral manifestations affecting platelets and clotting. It is characterized by spontaneous bleeding from mucosal tissues and excessive bleeding following skin damage. It belongs to the group of hereditary platelet disorders and is due to a defect in one of two genes, platelet membrane glycoprotein (GP) IIb/IIIa. Report A 22-year-old female patient with a history of Type I GT and long-term care using platelet transfusion was referred for management of her gingival bleeding. Dental treatment included scaling, polishing, oral hygiene instructions, along with a prescription for anti-plaque agents. There was pronounced improvement in her periodontal condition after treatment. Reduced gingival bleeding resulted in an increase in her hemoglobin level from a pre-treatment level of 2 gm% to 8 gm% during her last visit. The patient was followed for eight months with no further periodontal complications. Summary A pronounced improvement in the periodontal condition of a GT patient occurred following routine scaling and polishing procedures along with proper oral hygiene maintenance instructions. The result was a reduction of the patient's gingivitis and associated spontaneous bleeding and an improvement in her hemoglobin status. GT patients should be managed for their periodontal problems following a hematological consultation. The importance of proper maintenance of oral hygiene as well as regular recall visits should be emphasized. Citation Ambili R, NandaKumar K. Glanzmann Thrombasthenia: A Rare Hematological Disorder with Oral Manifestations: A Case Report. J Contemp Dent Pract 2008 July; (9)5:107-113.

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