DHEA sulphste was administered orally in doses of 20 to 80 mg to 13 subjects with hypercholesterolaemia or hyperlipaemia. Plasma lipid and neutral steroid eulphate levels aa well as the excretion of individual ll-deoxy-17-ketosteroids and estrogens in urine were investigated before and during the treatment. No effect was observed on plasma free or esterified cholesterol, on total or individual phospholipid values. or on routine blood haematological or chemical analyses. However, the plasma CIp steroid sulphate levels increased considerably as well aa the urinary excretion of the 11-deox 17-ketosteroids, indicating good absorption of the compoun$edminia-July 1,1971 tered. No significant changes in estrogen excretion following DHEA sulphate treatment could be noted.-When 13malesubjects with hypercholesterolaemia and hyperlipmia were compared with 42 normal controk of the same mean age, a sipficlmtly lower urinary excretion of dehydroepiandroeterone and estrone as well aa of eatronef eatradiol waa observed in the pathological series.