A comparative genetic examination of children with varying degrees of asthenization of the nervous system, living in the Far North of Russia was carried out. The polymerase chain reaction method on BioRAD CFX96 Real Time System was used to study the following polymorphisms: A1166C of AGTR1 angiotensin II receptor gene (rs5186), C1377T of calcitonin receptor gene CALCR (rs1801197), T/C of the clock period gene CLOCK (rs1801260) and G4682A of tumor necrosis factor (TNF) gene ( rs1800629). An associative relationship between these polymorphisms and the pathology of the nervous system in the climatic and geographic conditions of the Far North was established. Among the child population living in the Far North and having nervous system pathology a significant increase in the prevalence of variant alleles of genes providing the genetic determination of the development of asthenic-vegetative syndrome was shown due to angitensinogen associated processes of impaired cerebral vascular tone (AGTR1 rs5186), imbalance of seasonal and circadian rhythms underlying the processes of fatigue (CLOCK rs1801260), as well as impairment of optimal reception of processes of cell membrane regulation of the apoptosis procedure (CALCR rs1801197, TNF rs1800629).