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Present study is to investigate the effect of Gallic acid pretreatment on survival of septic animals and oxidative stress in different organs like lungs, liver, kidney, spleen, and vascular dysfunction of mice. Sepsis was induced by cecal ligation and puncture (CLP) in healthy adult male albino mice (25–30 g) and was divided into 3 groups each consisting of 6 animals, that is, sham-operated (SO group (Group I), SO + sepsis (Group II), and Gallic acid + sepsis (Group III)). Group III animals were pretreated with Gallic acid at the dose rate of 20 mg/kg body weight for 2 days before induction of sepsis. Animals were sacrificed on 8th day and the tissue samples were obtained for further investigation on lipid peroxidation (LPO), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione reductase (GSH). Gallic acid pretreatment significant (P < 0.05) reduces kidney, spleen, liver, and lungs' malondialdehyde level in septic mice. However, it fails to improve reduced glutathione level in all given organs, while, Gallic acid pretreated mice showed significant improvement in SOD activity of kidney and spleen when compared to septic mice. Finally, the beneficial effects of Gallic acid pretreatment in sepsis are evident from the observations that Gallic acid partially restored SOD and catalase activity and completely reversed lipid peroxidation. Further studies are required to find out the possible mechanisms underlying the beneficial effects of Gallic acid on large population.

Pisonia grandis R.Br (family: Nyctaginaceae) is a herb claimed to be used for treatment of inflammation, wound healing, algesia, and ulcer. The present study was done to evaluate the wound-healing potential of methanolic extract of its leaves. Following preliminary photochemical evaluation, the extract was incorporated in simple ointment base and evaluated using 2 types of wound models in Wistar rats-excision wound and incision wound. The results were significantly different ( p <0.05) when compared with control group for wound contraction, tensile strength, and histopathological and biological parameters. Antibacterial studies against different bacterial strains of the test samples were performed by the disk-diffusion method and were compared with standard ofloxacin and erythromycin. Test sample showed comparable zone of inhibition to the standards. It is hypothesized that the presence of phytoconstituents with the antibacterial effect helps in wound healing.

SUMMARYAyurveda, an ancient System of Indian Medicine, has recommended a number of drugs from indigenous plant sources for the treatment of inflammation. To evaluate the anti-inflammatory and analgesic activities of methanol extract of Triphala were investigated in Wister albino rats and mice. The methanol extract of Triphala were found to encompass substantial anti-inflammatory effect in acute and sub-acute models and analgesic effect. Animal models of carrageenan induced edema and cotton pellet induced granuloma in albino rats were used. Extract of 200 mg/kg shows significantly reduced paw edema. Analgesics activity of Triphala with 200 mg/kg shown by significant reduction of writhing. These report shows to support the use methanol extract of Triphala in relieving inflammation and pain.

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