A Sensitive, fast, linear and accurate liquid chromatography technique was developed for the simultaneous determination of Umeclidinium and Vilanterol in Powder dosage form. The estimation was carried out using Phenomenex C18 column (150 × 4.6 mm, 5μ) with ammonium acetate: acetonitrile taken in the ratio 60:40 as mobile phase and pumped at a flow rate of 0.9 ml/min at 300C. Detection wavelength selected was 245 nm. Retention times of Umeclidinium and Vilanterol were found to be 2.219 min and 2.794 min. The method was validated in terms of linearity, precision, accuracy, limit of detection, limit of quantification as per International council for harmonization guidelines. Degradation studies performed indicated the stability of the drug. All of these analytical validation parameters were evaluated, and the percent relative standard deviations were calculated, indicating the method's suitability for determination of Umeclidinium and Vilanterol in pharmaceutical dosage form.

Aripiprazole (APZ) is an antipsychotic drug that belongs to benzisoxazole derivatives and is used to treat schizophrenia as well as acute manic or mixed effects in patients with bipolar 1 disorder. APZ is used to treat certain mental, mood disorders such as bipolar disorder, Schizophrenia, Tourette's syndrome, and irritability associated with autistic disorder. It may also be used in combination with other medication to treat depression. The present review article would be useful for prospective studies for researchers interested in APZ formulation production and quality management. Using a thorough computer assisted literature survey; this review touches upon the various reported analytical methods for the quantification of APZ both in API (Active Pharmaceutical Ingredient) and pharmaceutical dosage forms. The present write-up also encompasses the various published research articles like Spectroscopy techniques, X- Ray Diffraction (XRD), Electro Chemical Technique, Differential Scanning Calorimeter (DSC) and Capillary Electrophoresis. This is the first review article in this series with focus on the analytical profile of APZ. Although, several methods were reported in the literature, HPLC stands out first for the quantification of APZ.