No abstract

Development and modification of Ayurvedic classical formulations into widely acceptable dosage forms is an important area to be focused in the present era. The designing of liquid dosage form has generally been emphasized on the basis of ease of administration to those individuals who have difficulty in swallowing solid dosage forms, specially in pediatric and geriatric group. Churna (powders) are the preferentially administered Ayurvedic formulations by oral route. Most of these powders are hygroscopic, bitter to taste and should be administered with suitable vehicle. Avipattikara Churna is one of the unique formulation widely practiced in the management of common ailments like Amlapitta (hyperacidity), Vibandha (constipation), Agnimandya (loss of appetite), Arsha (hemorrhoids). Modification of the classical Churna (solid dosage form) into a more acceptable and convenient syrup (liquid dosage form) with modern pharmaceutical methods and its physico-chemical analysis is the main aim of the study. In the present study Avipattikara syrup was developed with 66.7 % w/V of Khandasharkara (sugar candy powder) without any pharmaceutical additives. Physicochemical analysis, microbial limit test, and physical quality tests for Avipattikara Churna and syrup were carried out respectively. Results suggest that, the developed syrup had a quality of ideal syrup.

Background: The mode of action of a compound Ayurvedic formulation is a critical and essential issue to be concentrated in assuring the therapeutic efficacy and safety based on its composition. Avipattikara Churna is one of the commonly used formulations containing herbs-mineral drugs. Objective: To emphasize the rationality of Avipattikara Churna and its mode of action by classical and contemporary review. Data Source: Classical texts like Vangasena Samhita, Bhaishajya Ratnavali, Rasendra Sara sangraha, Rasendra Chintamani, and published research works. Material and Methods: In the present study a critical analysis based on ingredients and probable mode of action of Avipattikara Churna in different indicated clinical conditions like agnimandya (digestive impairment), vibandha (constipation), amlapitta (hyperacidity), arsha (piles), mutraghata (retention of urine) and prameha (diabetes mellitus) were done based on classical and contemporary research works. Result: Data from the critical review of classical and contemporary research works. Conclusion: Avipattikara Churna is a versatile formulation used in a wide range of gastrointestinal disorders. By this review, it can be emphasized that Avipattikara Churna, which is in clinical practice for Amlapitta (Hyperacidity) and vibandha (constipation) is a tailored formula by its ingredients. In-vivo studies not only justify the effectiveness of the formulation but provide more evidence of the safety and efficacy of the formulation. Clinical research works substantiate its significant gastroprotective activity.