Summary Although low doses of persistent organic pollutants (POPs), strong lipophilic chemicals with long half‐lives, have been linked to various endocrine, immune, nervous and reproductive system diseases, few obesity studies have considered adipose tissue as an important POPs exposure source. Because the toxicodynamics of POPs relate directly to the dynamics of adiposity, POPs might explain puzzling findings in obesity research. In two people exposed to the same amounts of environmental POPs, the one having more adipose tissue may be advantaged because POPs storage in adipose tissue can reduce burden on other critical organs. Therefore, adipose tissue can play a protective role against the POPs effects. However, two situations increase the POPs release from adipose tissue into the circulation, thereby increasing the risk that they will reach critical organs: (i) weight loss and (ii) insulin resistance. In contrast, weight gain reduces this possibility. Therefore, avoiding harmful health effects of POPs may mostly contradict conventional judgments about obesity and weight change. These contradictory situations can explain the obesity paradox, the adverse effects of intensive intentional weight loss and the protective effects of obesity against dementia. Future studies should consider that adipose tissue is widely contaminated with POPs in modern society.

The South Korean government carried out reforms in the occupational medical examination program over a period of 2 years from 1997 to 1998 in a response to the discontent of workers, who had complained that occupational medical examinations were merely ritualistic and unproductive. The purposes of this manuscript are to describe the reason for the remodeling, with a historical review of the existing occupational medical examination program in South Korea, and to discuss the main issues involved in remodeling the program. The existing occupational medical examination program in South Korea was reviewed and criticized. The basic philosophy and the main issues in remodeling South Korea's occupational medical examination program were also discussed. In conclusion, the occupational medical examination program should not be conducted in a uniform manner according to legal regulations, but should be a part of overall occupational health services. Individual workplaces should be given the autonomy to perform medical examinations according to the characteristics of the workplace. An enabling approach based on the participation of labor and management should be taken into consideration.