Objective: The objective of the work was to study the clinical profile of stroke in a tertiary care hospital.Methods: A prospective observational study on stroke was carried out for a period of 6-month (May 2015 to October 2015). A total of 241 inpatientsfrom Shri Preethi Hospital were incorporated in the study. The data were collected and evaluated by reviewing case files and patient interview.Result and Conclusion: Out of 241 patients, an incidence of ischemic stroke was found to be higher. The occurrence of stroke steeply rises with agewith male predominance. The burden of stroke tends to be more in rural, illiterate, and low socioeconomic status population. The study reveals riskfactors such as sedentary lifestyle, previous and family history of stroke, underlying disease like hypertension, diabetes. The circadian pattern in onsetshowed a significant peak in morning (6 am-12 pm) for Ischemic and afternoon (12 pm-6 pm) for hemorrhagic stroke. Topographic distribution ofcerebral infract and hemorrhage was found to be in parietal lobe and periventricular white matter, respectively. Mostly prescribed medication forischemic and hemorrhagic patients was antihypertensive and mannitol, respectively. The contraindication for thrombolytic therapy was found to below economic status and average delay in time of presentation to hospital. The study highlights the need for aggressive management of traditionalrisk factors, need for extensive work up in patient to find etiologies and need for more active interventions in community for the prevention of stroke.Keywords: Ischemic, Hemorrhagic, Circadian pattern, Antihypertensive.

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Natural products are the best source for the discovery of new drugs, which were in use even from the Vedic period. Development of standardized, safe and effective herbal formulation with proven scientific evidence can also provide an economical alternative in several diseases. Natural antioxidants are side effect free, used in preventive diseases and act as radical scavengers, inhibit lipid peroxiation and other free radical-mediated processes and therefore they protect the human body from several diseases attributed to the generation of radicals. There is evidence concerning the participation of reactive oxygen species (ROS) in the ethiology and pathophysiology of human diseases, such as neurodegenerative disorders, inflammation, viral infections, autoimmune pathologies and digestive system disorders, more so, in gastrointestinal inflammation and gastric ulcer. The ROS generated by the metabolism of arachidonic acid, platelets, macrophages and, smooth muscle cells may contribute to gastric mucosal damage. Therefore, by scavenging free radicals and the ROS, these herbs might be useful in protecting the gastric mucosa from oxidative damage and possibly may accelerate healing of gastric ulcers. Various phenolic antioxidants such as flavonoids, tannins, coumarins, xanthenes, procyanidinis have been reported to scavenge ROS in a dose dependent manner and, therefore are viewed as promising therapeutic agents for ameliorating free radicals-induced pathologies.

The present study is prospective and observational non-interventional study was conducted in tertiary care center. All suspected ADRs which are observed in hospital stay will be assessed for causality, severity, preventability and predictability. The results were presented as number and percentage. Among the 7697 cases ( both males and females), a total of 240 ADRs were detected, an overall incidence of 03.11 % adverse drug reactions in inpatients. The high prevalence of ADR mostly observed in the age group between 1-10 years 48 (20.00%)  From this 240 ADR’s where 7.96% on continuing t, 38.36% are recovering, 47.08% are recovered. Keywords: Adverse drug reaction, Causality, Severity, Preventability, Probability.