In 1866, Ebstein described the post-mortem findings of a 19-year-old boy who died in congestive heart failure. The tricuspid valve was replaced by a large membrane, originating from the annulus fibrosus and from the anterior and posterior portions of the endocardium of the right ventricle and the interventricular septum and the septal cusp was displaced downwards 15 mm. from the annulus a patent foramen ovale was uncovered and multiple defects were present in the septum primum.Since

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