We aimed to estimate the household secondary infection attack rate (hSAR) of SARS‐CoV‐2 in investigations aligned with the WHO Unity Studies Household Transmission Investigations (HHTI) protocol. We conducted a systematic review and meta‐analysis according to PRISMA 2020 guidelines. We searched Medline, Embase, Web of Science, Scopus and medRxiv/bioRxiv for “Unity‐aligned” First Few X cases (FFX) and HHTIs published 1 December 2019 to 26 July 2021. Standardised early results were shared by WHO Unity Studies collaborators (to 1 October 2021). We used a bespoke tool to assess investigation methodological quality. Values for hSAR and 95% confidence intervals (CIs) were extracted or calculated from crude data. Heterogeneity was assessed by visually inspecting overlap of CIs on forest plots and quantified in meta‐analyses. Of 9988 records retrieved, 80 articles (64 from databases; 16 provided by Unity Studies collaborators) were retained in the systematic review; 62 were included in the primary meta‐analysis. hSAR point estimates ranged from 2% to 90% (95% prediction interval: 3%–71%; I2 = 99.7%); I2 values remained >99% in subgroup analyses, indicating high, unexplained heterogeneity and leading to a decision not to report pooled hSAR estimates. FFX and HHTI remain critical epidemiological tools for early and ongoing characterisation of novel infectious pathogens. The large, unexplained variance in hSAR estimates emphasises the need to further support standardisation in planning, conduct and analysis, and for clear and comprehensive reporting of FFX and HHTIs in time and place, to guide evidence‐based pandemic preparedness and response efforts for SARS‐CoV‐2, influenza and future novel respiratory viruses.

Background: Animal bites cause a big burden in terms of morbidity and mortality throughout the world. These bites could be caused by rabid animals causing rabies. Annually about 59,000 persons die of rabies, of which 20,000 is from India alone. Rabies though 100% fatal is preventable with post-exposure prophylaxis which includes wound wash, anti-rabies vaccination (ARV) and rabies immunoglobulin. The objectives of the present study was to describe the demographic profile of animal bite cases and to assess the management practices of animal bite cases reporting to dedicated anti-rabies clinic (ARC) of a tertiary care hospital, Hassan, Karnataka.Methods: A cross-sectional study was conducted from the inception of anti-rabies clinic (12th October 2017) to August 2018 among animal bite cases reported to ARC. They were interviewed by using a semi-structured, pre-designed and pre-tested proforma. Data regarding socio-demographic profile were collected from the animal bite victims. All the animal bite cases were managed as per WHO guidelines.Results: The total number of animal bite victims reported to ARC during the study period was 3500. Majority of the bite victims belonged to adult population (20-60 years). Majority were males (66.2%). 77% belonged to the rural population. Dogs (97.1%) were the most common biting animal. 79% of the bites were provoked. Turmeric powder was the most commonly used irritant. Most bites belonged to Category III (84%). Category I, II, III bites were managed appropriately according to WHO guidelines.Conclusions: Knowing the burden, socio-demographic characteristics and the management of animal bite victims in the dedicated ARC of HIMS has helped the programme officer in implementing the National Rabies Control Programme in Hassan district.

This study, using the cobalt chloride technique, clarifies the origin of the giant axons in the cockroach, Periplaneta. Each giant axon in the ventral nerve cord arises from a single cell body located in the sixth abdominal ganglion. The position of the soma is always contralateral to the giant axon; it projects anteriorly. In six giant neurons, the axonic and dendritic branches are ipsilateral while the somata are contralateral. In two neurons, both the soma and the dendritic branches are ipsilateral while the axons are contralateral. The dendritic arborizations of the giant neurons form a dense and compact mass of neuropile in each half of the posterior and middorsal part of the ganglion where sensory fibers, primarily from the cercal nerves terminate. The relation of these findings to earlier electrophysiological studies is discussed.

The plant species belong to the family Loranthaceae (mistletoe family) are hemi parasites. Dendrophthoe falcata is a large bushy evergreen stem hemiparasite. It can capture food from the host trees by means of penetrating roots called the haustoria. This epiphytic parasite found generally on various host plants in large amounts worldwide and causes much damage to economical cultivated plants and also grown on different host plants throughout India. As hemiparasite it is associated with tropical trees specifically the mango trees and rarely few timbers yielding trees. It has been reported to have increased its host range and found growing on varieties of trees. The species of Dendrophthoe falcata commonly known as Loranthus are common parasitic flowering plants occur all over India and cause severe damage to the field crops. However, comprehensive reports on the occurrence of this parasite, host range, effect on crop production, management practices are not available in the country. Under these circumstances the present study was undertaken to identify the species of Loranthus attacking a fruit yielding crop mango (Mangifera indica) cultivated in and around Vizianagram District, Andhra Pradesh to observe their parasitic relationship with their host plants.

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