Introduction: Leaf extracts of Moringa oleifera (aqueous, diethyl ether, ethanol, and ethyl acetate) were tested on Echerichia coli, Pseudomonas aeroginosa, Staphylococcus aureus, Salmonella typhi, Streptococcus pyogenes and Klebsiella aerogenes using agar well diffusion method. Methods: Antibiotics (control) used were tetracycline and ciprofloxacin at 250 mg/mL. Results: Results obtained showed that 200 mg/mL of diethyl ether, ethanol, ethyl acetate and 100% aqueous extracts had more effect than 160 mg/mL of diethyl ether, ethanol, ethyl acetate and 80% aqueous respectively. The results showed that Salmonella typhi was more susceptible than other organisms and ethyl acetate extract was more effective than other extracts. The phytochemical screening indicated the presence of flavonoid, alkaloids, tannin, glycoside, saponin, and phenol. Conclusions: The study showed that Moringa oleifera can be used as potential herbs for treatment of bacteria pathogens tested in this study and these activities could be attributed to the presence of these secondary metabolites.