A representative and randomized study of the effect of a combination of nanosilver and a new injection form of Rexod® on the periodontal tissues state of animals (rats) in an experimental model of inflammatory pathology of periodontal tissues (experimental periodontitis) was carried out. It was shown that the improvement of the dental status of periodontal tissues against the background of the course application of a combination of nanosilver (topically) and a new injection form of Rexod® was accompanied by a decrease in the amount of gingival fluid of the sulcular gingival sulcus, an improvement in the clinical condition of the marginal periodontal mucosa (hyperemia was leveled, swelling decreased, the bleeding indexPBI Muhllemann-Cowell decreased, test Schiller-Pisarev results normalised). The decrease in the number of gum fluids is due to the decrease in antibacterial activity of pathogenic microflora and their products of their life-based hemodynamics of the peripheral microvascular network (exchange capabulars) of the periodontal, a decrease in perfusion pressure in them, reduced (narrowing) of their lumen, reduce their permeability and restoration of oxidation-reduction processes.

It is shown that in experiments on narcotic male rats of the Wistar line using laser Doppler flometry (LDF) under conditions of induced (ligature) experimental periodontitis (EP), indicators of blood microcirculation in the gum mucosa in the lower incisors is reduced compared with intact periodontium. When using traditional drug therapy (TDT) in the conditions of EP in the selected localization, observed a significant promotion in blood microcirculation after a 12-day period of treatment. However, on the 74th day of the study, it decreases. The use of TDT in combination with gel, containing cluster silver in the form of micelle monomers and cluster monomers of the AgK+ type and superoxide dismutase, and a new injectable form, which is a recombinant human superoxide dismutase, under EP conditions in the selected field of study both after applying the pharmacological composition for twelve days, and on the 74th day of the experiment caused an increase in microcirculation to the original values.

Introduction: Periodontitis is one of the most urgent problems of modern dentistry. The development of new paradigms and regimens of combination therapy of patients with periodontitis is a strategic task for pharmacologists and dentists. In view of this, pathomorphological examination is of high importance, since it allow us to conclude about the therapeutic effectiveness of the administered drugs with high objectivity. Aim of the study: to evaluate the effect of the composition of Soderm®-Forte and Cytoflavin® on the pathomorphological pattern of gum tissues of rats with experimental periodontitis (EP). Materials and Methods: EP was simulated in rats by ligature method. Study design: animals with intact periodontium; animals with untreated EP; animals with EP treated with traditional drug therapy (TDT); animals with EP treated with the combination of TDT and Soderm®-Forte gel; and animals with EP treated with the combination of TDT, Soderm®-Forte and Cytoflavin®. For pathomorphological examination, biopsy specimen was taken from the gingival margin of the lower incisors. Slides were stained with hematoxylin and eosin, as well as by Masson. Computer morphometry was performed using the ImageJ software. Results: In EP, TDT has a moderate positive effect on pathomorphological changes in the gum. The combination of TDT and Soderm®-Forte and, to a greater degree, the combination of TDT, Soderm®-Forte and Cytoflavin® have high therapeutic efficacy, characterized by rapid regeneration of the gum tissues.  Conclusion: The combination of TDT, Soderm®-Forte and Cytoflavin® in EP has a more pronounced therapeutic effect, manifested by early regression of pathological changes and acceleration of tissue regeneration in the gum. Graphical Abstract