Nickel(II) reacts with 2-acetylpyridine-4-methyl-3-thiosemicarbazone (APMT) and forms a yellow colored complex, which was extracted into n-hexanol from sodium acetate and acetic acid buffer at pH 6.0. The absorbance value of the Ni(II)-APMT complex was measured at different intervals of time at 375 nm to ascertain the time stability of the complex. The extraction of the complex into the solvent was instantaneous and stable for more than 72 hrs. The system obeyed Beer’s law in the concentration range of 0.235 - 2.43 µg·ml^–1 of nickel(II), with an excellent linearity and a correlation coefficient of 0.999. The molar absorptivity and Sandell’s sensitivity of the extracted species were found to be 2.16 × 104 L mol^–1 ·cm^–1 and 0.003 µg·cm^–2 at 375 nm, respectively. Hence a detailed study of the extraction of nickel(II) with APMT has been undertaken with a view to developing a rapid and sensitive extractive spectrophotometric method for the determination of nickel(II) when present alone or in the presence of diverse ions which are usually associated with nickel(II) in environmental matrices like soil and industrial effluents. Various standard alloy samples (CM 247 LC, IN 718, BCS 233, 266, 253 and 251) have been tested for the determination of nickel for the purpose of validation of the present method. The results of the proposed method are comparable with those from atomic absorption spectrometry and were found to be in good agreement

Kadara is a Kshudra Roga, first mentioned by Acharya Sushruta. It is a condition which causes extreme pain and discomfort to the affected person. Kadara may be correlated to Corn based on the causative factors, site of the swelling, clinical and other features. The incidence of corn in India is more than 10 million cases per year. The treatment modalities available at present in the modern science are the usage of corn caps, salicylic acid paints, cryotherapy and surgical excision. All theses modalities are associated with a high rate of recurrence. Snehadahana is mentioned as the line of management in Kadara after Utkarthana by all the Acharyas. Acharya Bhoja specifically mentions Tila Thaila as the Sneha dravya to be used for Agnikarma. In the present study, a 53 year old female patient, who visited the OPD of Sri Jayendra Saraswathi Ayurveda College and Hospital with a case of Kadara, was selected for Snehadahana. Chedana was done prior to Snehadahana. The procedure was carried out as 4 sittings, once a week, for a period of 4 weeks. Two follow ups were done at an interval of 14 days, after the fourth sitting of Snehadahana. There was complete healing of the wound and no recurrence seen until the follow up period.

Alcaftadine is an active pharmaceutical ingredient (API) used as an ophthalmic solution for the prevention of itching associated with allergic conjunctivitis. The originally reported synthesis uses a time-consuming column chromatography technique for the isolation of hydroxymethylated product alcohol (10). A simple yet effective double oxidation strategy is developed using oxidation grade manganese dioxide to avoid tedious chromatographic purification. Firstly, a partial oxidation of hydroxymethylated crude mass (mixture of compounds 9, 10 and 16) was carried out using a limited amount of MnO2 to get rid of critical diol impurity (16) and to allow crystallization of alcohol (10) crude, followed by its second oxidation using additional MnO2 to provide alcaftadine via a scale-up friendly process. This synthetic approach has been proven to be cost effective and commercially viable. Various impurities formed during the process were also identified and eliminated to obtain ICH guideline purity of alcaftadine API. The process was validated in plant scale and US DMF was filed to manufacture alcaftadine API.

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