Background
Paracetamol (acetaminophen) toxicity is considered to be one of the major causes of drug-induced hepatic failure.
Citraka
(
Plumbago rosea
L. and
Plumbago zeylanica
L.) was mentioned in Ayurveda classics as a remedy in liver disorders.
Objective(s)
The aim of the study was to experimentally evaluate the comparative effect of hepatoprotective activity of detoxified root decoction of the two species of
Citraka
against paracetamol-induced hepatotoxicity in male Wistar albino rats.
Materials and methods
The hepatoprotective effect of
Citraka
decoction of two species was evaluated by the assessment of biochemical parameters such as SGOT, SGPT, alkaline phosphatase, total bilirubin, direct bilirubin, and serum creatinine. The study was also supported by histopathological assessment of liver sections.
Results
The results showed the elevated concentration of biochemical markers and histopathological degenerative changes in animals treated with paracetamol indicating severe hepatic damage; whereas, the treatment with decoction of both the species of
Citraka
showed significant reduction in the serum markers and regenerative changes in the histopathological specimens pointing towards its effectiveness as a hepatoprotective drug.
Conclusion
The present study showed
Citraka
’s effectiveness as a hepatoprotective drug and proved that the detoxified root decoction of
P. rosea
L. has a significant protective activity against paracetamol-induced hepatotoxicity than
P. zeylanica
L.
Dandruff is a common scalp disorder affecting almost half of the population. According to Ayurveda, Dandruff may be correlated to Darunaka. Ayurveda classics dealt different procedures and medications to treat the disease Darunaka (dandruff). The present study is based on the reference from Cikitsamanjary by Sreeman Nambootiri, an authentic Ayurveda book. Haritaki mixed with Takra (buttermilk) as Sirolepa (application of paste over the scalp region) is used to reduce Darunaka. Darunaka is a Kapha Vata predominant disease having the symptoms like Kandu (Itching), Kesha Chyuthi (Hair fall), Twak sphutana (Scaling) and Rukshata (Dryness). Haritaki is having Lavanavarjitha Pancha Rasa, Laghu Ruksha Guna, Ushna Virya, Madhura Vipaka and Tridoshahara property (Pharmacological properties). Takram is having Laghu Ruksha Guna, Kasaya, Amla rasa; Ushna Virya and Madhura Vipaka with Kapha Vatahara property. In the clinical study, 30 patients of Darunaka were selected as per inclusion and exclusion criteria. The study was effective in reducing the symptoms of Darunaka.
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