Intravenous silica injections were used to assess the role of macrophages in the resistance of BALB/c nude and euthymic mice to systemic candidosis. CFU of Candida albicans in the kidneys, livers, and spleens of salineor silica-treated mice were enumerated at various times after inoculation with 104 viable yeast cells. The number of C. albicans organisms recovered from the kidneys of silicatreated euthymic mice was similar to the number recovered from saline-treated controls during the first 3 days of infection; however, at every assay period thereafter, the number of organisms recovered from the kidneys of silica-treated mice was dramatically reduced (100to 1,000-fold). Conversely, silica-treated nude mice were no more susceptible to systemic candidosis than were salineinjected nude mice. Silica treatment did not alter the ability of treated or control mice to clear C. albicans from the liver and spleen. These results demonstrate that macrophages play an important role in susceptibility to Candida infections.
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