Observations in 3 patients demonstrated, that joint-bleedings can be controlled with high doses of fraction FEIBA alone or in combination with factor (f) VIII on out-patient basis. First patient, inhibitor 5-10 units (u) per ml, suffered from 24 joint-bleedings within 392 days. 2o of them could be stopped by a single injection of 150-200 u of fraction FEIBA per kg bodyweight (bw). A combination of 90 u of FEIBA and 36 u of f VIII per kg bw had the same effect. But after 5 injections of this combination within 6 weeks, the inhibitor level had risen from 10 to 240 u per ml. During further treatment with 180 u of fraction FEIBA without addition of f VIII, the inhibitor fell down with a half life time of 50 days. The clinical effect of fraction FEIBA was not influenced by the elevated antibody level. Two further patients, inhibitors 2-4 and 32 u respectively, obtained combined injections of 50-100 u of FEIBA plus 36-42 u of f VIII. One patient was on a prophylaxis of 3 injections weekly for 193 days. After 57 injections the inhibitor had fallen from 2-4 u to unmeasurable values. The third patient obtained the above mentioned dosis twice a day for treatment of a knee joint effusion. After 1 week the inhibitor was diminished from 32 to 13 u.

No abstract

No abstract

This paper presents the hardware-in-the-loop (HIL) test of the demand as frequency controlled reserve (DFR). The HIL test refers to a test in which parts of a pure simulation have been replaced by actual physical components. It is used to understand the behavior of a new device or controller. The DFR has been tested by offline simulations to illustrate the efficacy of this technology. The DFR control logics have been implemented in the SmartBox. The HIL was conducted by having the SmartBox connected to the real time simulations and the performance of the SmartBox was tested with difference frequency events in the simulated power systems. The HIL test results show that the implemented DFR in the SmartBox can efficiently arrest the system frequency.

Dieses Dokument wurde zum persönlichen Gebrauch heruntergeladen. Vervielfältigung nur mit Zustimmung des Verlages.