Water-distilled essential oils from herbal parts of Tanacetum parthenium from two different localities in Turkey were analyzed by GC and GC/MS. The essential oil of T. parthenium collected from Davutpaşa-İstanbul location were characterized with camphor 49%, trans-chrysanthenyl acetate 22.1% and camphene 9.4%. Second plant sample is collected from the remote east end of the country Şavşat-Ardahan location. The essential oil from this location was characterized with camphor 60.8% and camphene 6.8%. Unlike the former this sample contains trans-chrysanthenyl acetate in trace amount and cis-chrysanthenyl acetate in very small amount (0.6%) which is not present in the first sample. Antibacterial activity of the oils were evaluated for five Gram (+) and five Gram (-) bacteria by using a broth microdilution assay. The highest activity was observed on Bacillus subtilis, Staphylococcus aureus and methicillin-resistant S.aureus however when compared with positive control oils showed higher MIC values. The oil of İ stanbul-sample showed highest activity on B. subtilis (125 mg/mL) and methicillinresistant S. aureus (125 mg/mL) which is two fold concentration when compared with the positive control chloramphenicol (62.5 mg/mL). The oil of Ardahan sample showed the highest activity on S. aureus (125 mg/mL) which is likewise two fold concentration of the positive control chloramphenicol (62.5 mg/mL). DPPH scavenging activity was 59.3% of the oil from Davutpaşa at 15mg/mL concentration. When compared to positive control a-tocopherol (94.6%) Şavşat oil (28.2%) showed low and Davutpaşa oil showed medium DPPH scavenging activity. All of the oils showed toxicity to Vibrio fischeri in the TLCbioluminescence assay.

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