BACKGROUND: Acne vulgaris (AV) is a chronic inflammatory disease in the pilosebaceous unit. Recent research has begun to focus on the essential relationship between oxidative stress and the pathogenesis of AV. The use of antioxidants like coenzyme Q10 (CoQ10) that has various advantages as adjuvant therapy is expected to be beneficial for AV. AIM: The study was aimed to analyze the effect of CoQ10 supplementation on serum SOD levels and the severity of AV patients. METHODS: A double blind-randomized controlled trial was carried out on 36 patients with AV and classified according to severity degree of AV. These patients were randomly divided into two groups (treatment group with tretinoin 0.025% cream and once-daily supplementation of CoQ10 100 mg tablet; and placebo group with tretinoin 0.025% cream and once-daily placebo tablet). Response to treatment was based on serum superoxide dismutase (SOD) level and AV severity degree. RESULTS: Administration of CoQ10 to AV patients significantly increase serum SOD level (p = 0.008) and improves the severity of AV after 8 weeks (p = 0.008). CONCLUSION: CoQ10 supplementation can increase serum SOD levels and improve the severity of AV.

Background : Leprosy (Morbus Hansen) is a chronic infectious disease caused by the bacterium Mycobacterium leprae. This disease is a type of granulomatous disease in the peripheral nerves and mucosa of the upper respiratory tract; and skin lesions are signs that can be observed from the outside. If left untreated, leprosy can be very progressive, causing damage to the skin, nerves, limbs, and eyes.Methods : This research used case control study design 248 subjects selected by simple random sampling. The variables studied were age, sex, education level, occupation, BCG vaccination status, nutritional status, open wound history, chemoprophylaxis drug adherence, family economic condition, personal hygiene and home conditions. Data were analyzed using chi square test for bivariate test and multiple logistic regression.Results : Duration of contact with patient (p=0,050; OR=1,88; 95%CI=1,000-3,534), BCG vaccination status (p=0,014; OR=2,12; 95% CI=1,161-3,881), nutritional status less (p=0,000; OR=6.01; 95%CI=3,188-11,331), open wound (p=0,002; OR=0,37; 95%CI=0,200-0,699), economic condition of low income family (p=0,000; OR=3.07; 95% CI=1,653-5,715). poor personal hygiene (p= 0.001; OR= 2.99; 95% CI= 1.583-5.569).Conclusion : Factors that have been proven to have an effect on the incidence of leprosy after chemoprophylaxis are low education level, ≥1 year contact duration, poor nutritional status, poor family income economic condition and poor personal hygiene. Factors ≥1 year contact duration, no grated BCG vaccination status, poor nutritional status, history of open wounds, poor family income economic condition and poor personal hygiene have probability of incidence leprosy were 90%.

Objective: The objective of this research is to evaluate the effect of black tilapia sh/BTF (Oreochromis niloticus) skin extract cream application on wound healing by assessing its effect on wound contraction, epithelial thickness, and collagenization rate. T Method: rue experiment using 36 Rattus norvegicus as research object, wounded with punch biopsy sized 8 mm on right side of the back. Research objects were divided into 6 groups (X0: no treatment; X1: cream base application on wound; X2: application of gentamicin cream; X3: application of BTF extract cream 10%; X4: application of BTF extract cream 20%; X5: application of BTF extract cream 30%. Wound contraction was evaluated on day 3, 6, 9, and 11. Tissue sample was biopsied and examined on day 11 to evaluate epithelial thickness (HE) and collagenization (mallory). Application of Result: BTF skin extract cream showed an effect on wound contraction, epithelial thickness, and collagenization rate of new wound, the higher the concentration of BTF cream given, the better the result was. BTF skin extrac Conclusion: t cream can be a new hope and alternative therapy in wound treatment.

Background : Leprosy (Morbus Hansen) is a chronic infectious disease caused by the bacterium Mycobacterium leprae. This disease is a type of granulomatous disease in the peripheral nerves and mucosa of the upper respiratory tract; and skin lesions are signs that can be observed from the outside. If left untreated, leprosy can be very progressive, causing damage to the skin, nerves, limbs, and eyes.Methods : This research used case control study design 248 subjects selected by simple random sampling. The variables studied were age, sex, education level, occupation, BCG vaccination status, nutritional status, open wound history, chemoprophylaxis drug adherence, family economic condition, personal hygiene and home conditions. Data were analyzed using chi square test for bivariate test and multiple logistic regression.Results : Duration of contact with patient (p=0,050; OR=1,88; 95%CI=1,000-3,534), BCG vaccination status (p=0,014; OR=2,12; 95% CI=1,161-3,881), nutritional status less (p=0,000; OR=6.01; 95%CI=3,188-11,331), open wound (p=0,002; OR=0,37; 95%CI=0,200-0,699), economic condition of low income family (p=0,000; OR=3.07; 95% CI=1,653-5,715). poor personal hygiene (p= 0.001; OR= 2.99; 95% CI= 1.583-5.569).Conclusion : Factors that have been proven to have an effect on the incidence of leprosy after chemoprophylaxis are low education level, ≥1 year contact duration, poor nutritional status, poor family income economic condition and poor personal hygiene. Factors ≥1 year contact duration, no grated BCG vaccination status, poor nutritional status, history of open wounds, poor family income economic condition and poor personal hygiene have probability of incidence leprosy were 90%.