Lipidomics is defined as the analysis of lipids on the systems-level scale together with their interacting factors. In this review, we will discuss the technical developments in the field of lipidomics and overview the current state of the lipid bioinformatics field as well as suggest few potential new areas of research. The role of bioinformatics in the development of lipidomics will also be discussed.

Both genetic and environmental factors have been implicated in the mechanism of various disorders. Epidemiological data have shown that environmental factors can also cause and/or exacerbate the pathogenesis of these diseases. However in this article, we provide a summary of evidence for environmental and genetic factors influencing the diseases. The review also incorporates the major findings categorizing the common diseases on the basis of genetic profiles and ethnic information and in establishing personalized disease diagnosis, drug responses and treatment modalities based on the genetic determinants. These studies provide important insights into the interplay between environmental and genetic factors leading to human diseases. Overall an attempt has been made to highlight the importance of studying the genetic profiles of an individual with many factors.

Metabolomics is the newly emerging field of 'omics' research.Its Comprehensive and simultaneous systematic determination of metabolite levels in the metabolome and their changes over time.This review outlines how metabolomics is emerging in today's life. It presents metabolomics methodology and focuses on the current and potential applications of metabolomics in different diseases with particular attention to its use as a biomarker in diagnosis, prognosis, and therapeutic evaluation. We think this review will appeal to both translational researchers and clinicians as it reviews up-to-date evidence on the utility of metabolomics, an often poorly understood topic. The report also highlights the use of metabolomics in maximizing and sustaining revenues post-marketing and in the development of clinical diagnostics.

Neurological disorders are diseases of the central and peripheral nervous system. In this Review, It has been analysed epigenetic changes present in neurological diseases and discussed its therapeutic potential. The article has reviewed advances and considers approaches that may provide hope for alleviation of the disorders. This also reviews in this supplement focus on the neurobiology of a variety of these diseases of the central nervous system (CNS), including epilepsy, Alzheimer's disease (AD), Parkinson's disease (PD) and multiple sclerosis (MS).

The collection of global metabolic data and their interpretation (both spectral and biochemical) using modern spectroscopic techniques and appropriate statistical approaches, are known as `metabolomics'. This review covers research on metabolomics, ranging from the development of specialized chemical analytical techniques to the construction of databases and methods for metabolic simulation. Furthermore we have also outlined the recent developments in elucidating the system-level functions of the bioconstituents of living organisms. Metabolomics has the potential to serve an important role in diagnosis and management of human conditions. As such the purpose of this systematic review is to summarize existing literature on metabolomics and its various techniques in terms of diagnostic accuracies and distinguishing metabolites. This article has also highlighted the novelty of the field of metabolomics with various detection methods. Here metabolomic methodologies are discussed briefly followed by a more detailed review of the use of metabolomics in integrated applications where metabolomics information has been combined with other "omic" data sets (proteomics, transcriptomics) to enable greater understanding of a biological system.