Emergent resistance to antibiotics among Streptococcus pneumoniae isolates is a severe problem worldwide. Antibiotic resistance profiles for S pneumoniae isolates identified from pediatric patients in mainland China remains to be established. The clinical features, antimicrobial resistance, and multidrug resistance patterns of S pneumoniae were retrospectively analyzed at 10 children's hospitals in mainland China in 2016. Among the collected 6132 S pneumoniae isolates, pneumococcal diseases mainly occurred in children younger than 5 years old (85.1%). The resistance rate of S pneumoniae to clindamycin, erythromycin, tetracycline, and trimethoprim/sulfamethoxazole was 95.8%, 95.2%, 93.6%, and 66.7%, respectively. The resistance rates of S pneumoniae to penicillin were 86.9% and 1.4% in non-meningitis and meningitis isolates, while the proportions of ceftriaxone resistance were 8.2% and 18.1%, respectively. Pneumococcal conjugate vaccine was administered to only 4.1% of patients. Penicillin and ceftriaxone resistance, underling diseases, antibiotic resistant risk factors, and poor prognosis appeared more frequently in invasive pneumococcal diseases. The incidence of multidrug resistance (MDR) was 46.1% in patients with invasive pneumococcal disease which was more than in patients with non-invasive pneumococcal disease (18.3%). Patients with invasive pneumococcal disease usually have several MDR coexistence. S pneumoniae isolates showed high resistance to common antibiotics in mainland China. Penicillin and ceftriaxone resistance rate of invasive streptococcal pneumonia patients were significantly higher than that of non-invasive S pneumoniae patients. Alarmingly, 46.1% of invasive clinical isolates were multidrug resistant, so it is important to continued monitor the resistance of S pneumoniae when protein conjugate vaccine (PCV13) is coming in mainland China.

Title pageClinical and laboratory characteristics of childhood brucellosis in high-risk area of Western China

Wind turbines are one of the key systems in wind energy development. The wind tower supporting the whole wind turbine is a towering structure, which has been affected by installation, transportation, environment, and other factors. Furthermore, it is prone to experience other quality problems that would be difficult to detect for wind turbine towers. Therefore, the key to maintain the wind tower structure and to ensure the normal operation of a wind turbine is to carry out comprehensive and detailed detection and monitoring studies during its service stage. This paper sorted out several common quality problems including structural damage, deformation, flange bolts loosening, and corrosion of wind tower and relevant research on the detection and monitoring of these quality problems. In addition, some nondestructive testing technologies are introduced, including the ultrasonic phased array, time of flight diffraction, magnetic memory, acoustic emission, fiber Bragg grating and piezoelectric impedance, and applications in wind turbine towers.

In the aim at developing and utilizing ferrous mill tailing resources to save energy, protect environment and develop sustainable society, the experimental study on ferrous mill tailing (FMT) concrete are carried out. The strength grades of concrete used in tests are C30, C35, C40, C45, C50 and C55. Based on the compressive tests, the cubic strength and prism strength of FMT concrete along with their relationship were obtained. Meanwhile, with prism compressive test, the elastic modulus of FMT concrete and its relationship with compressive standard strength also were obtained. The test results show that the ratio of prism compressive strength to cubic compressive strength for FMT concrete is about 0.8-0.9 and the FMT concrete elastic modulus increase with its strength grades.