Photocatalytic degradation technology, using solar energy as the driving force, is considered the most possible alternative to remediate environmental pollution. And it is essential to find a stable and efficient photocatalyst. As promising semiconductor-based photocatalysts, Cu 2 O has acquired massive attention owning to its high conduction band energy, superior visiblelight response-ability, low cost, eco-friendly, and abundance. However, the application of origin Cu 2 O faces severe problems due to its photocorrosion and low photoinduced carrier separation. Consequently, it is necessary to improve its photo-stability and photocatalytic activity by carrying out numerous modification strategies, such as heterostructure construction. Herein, we first summarize the classification and operation principles of Cu 2 O-based type-II heterojunction. Then, the application of the Cu 2 O-based type-II heterojunction photocatalysts for the removal of tetracyclines, quinolones, and sulfonamides have been discussed. Finally, the pressing issues and perspectives in Cu 2 O-based type-II heterojunction photocatalysts application for degrading antibiotics have prospected.