Gallstones have been linked to dyslipidemia, metabolic syndrome and cardiovascular disease. Arterial stiffness is an indicator of subclinical atherosclerosis. The aim of this study was to prospectively examine the relationship between gallstone disease and arterial stiffness progression in 347 men and 454 women. These subjects were followed for 7 years. Arterial stiffness progression was measured based on increases in brachial-ankle pulse wave velocity. Changes in brachial-ankle pulse wave velocity during the study period were significantly greater in patients with gallstones than in subjects without gallstones. After adjusting for multiple risk factors, gallstone disease was found to be a significant and independent predictor of brachial-ankle pulse wave velocity progression (β=0.189; P<0.001). In conclusion, gallstone disease is an independent predictor of arterial stiffness progression, even after adjusting for other cardiovascular risk factors.

Objective To determine the effect of ropivacaine on peripheral neuropathy in diabetic rats and its possible mechanism.Methods Forty-eight Sprague–Dawley rats were randomly divided into six groups: nondiabetic control group, nondiabetic group A (0.25% ropivacaine), nondiabetic group B (0.75% ropivacaine), diabetic control group (diabetic peripheral neuropathy (DPN) +artificial cerebrospinal fluid), diabetic group A (DPN+0.25% ropivacaine), and diabetic group B (DPN + 0.75% ropivacaine), with eight rats in each group. Within an hour of the last administration, the sciatic motor nerve conduction velocity (MNCV) of each group was measured, and the morphological changes of rat sciatic nerve were observed by HE, Weil’s staining and electron microscopy. The expression of transient receptor potential vanilloid (TRPV1) in the spinal cord dorsal horn of rats was analyzed by immunohistochemistry, and the expression of Calcitonin gene-related peptide (CGRP) protein in the spinal cord was analyzed by Western blot.Results Compared with the nondiabetic control group, elevated blood glucose, decreased weight and reduced average mechanical withdrawal threshold (MWT), additionally, the sciatic nerves showed significantly slowed conduction velocity (both P<0.001) and damaged pathological structure, the expression of TRPV1 and CGRP were decreased (both P<0.001) in the diabetic groups. Compared with the diabetic control group, down-regulation of TRPV1 and CGRP in spinal cord was significant for the diabetic groups A and B treated with 0.25 and 0.75% ropivacaine, the higher concentration of ropivacaine correlated with a greater change.Conclusion Ropivacaine can significantly block sciatic nerve conduction velocity in DPN rats in a concentration-dependent manner, which may be related to the expression of the TRPV1-CGRP pathway.

Background: Dyslipidemia is a factor affecting the occurrence and development of many chronic diseases. With its prevalence increasing year by year, dyslipidemia has caused a huge burden of disease and economy in China and even the world. Appropriate health management is imperative for people with risk factors for dyslipidemia. However, the traditional health management service models mainly focus on the population with chronic diseases. Therefore, we need to establish new models of health management services to more appropriately manage people with risk factors for dyslipidemia. Methods: Among the 5 administrative districts with a population of more than 100,000 in Shenyang, 23 community health service centers with an average daily outpatient number of more than 50 were selected. A total of 5,032 subjects with risk factors for dyslipidemia who met the inclusion criteria were included in this study. Using prospective cohort study methods. The subjects were followed up for 24 months. They were randomly divided into control group and test group , and received integration of general practice and personalized disease prevention in health management (IGPDP) or traditional health management services, respectively. We analyzed and compared changes in disease prevention, health protection, and health promotion between the two groups at baseline, 12 months after the intervention, and 24 months after the intervention.Results: In terms of disease prevention, we found that after the intervention, participants' behavioral risk factors (smoking, diet, sedentary) improved and their health literacy improved. In terms of health protection, we observed a decrease in BMI (biological risk factor), a gradual improvement in blood lipid levels, and an overall increase in quality of life scores. In terms of health promotion, after the intervention, the proportion of the subjects willing to accept the contracted services of general practitioners increased.Conclusion: IGPDP can effectively cultivate healthy lifestyle of subjects, improve health literacy, reduce biological risk factors, reduce the risk of dyslipidemia, and improve subjects' quality of life. IGPDP is conducive to improving the service quality of general practitioners, the trust of the general public, and facilitating the establishment of a hierarchical medical system.