HLA-Cw6 is strongly associated with psoriasis and has been suggested to be the PSORS1 gene that confers susceptibility to early-onset psoriasis. In this study of the clinical features of HLA-Cw*0602-positive and -negative psoriasis patients in a Han Chinese population, we typed HLA-C in a cohort of 679 patients and compared the two groups. Cw*0602-positive patients (n=345) had an earlier disease onset (p < 1 x 10(-5)), more severe disease (p < 1 x 10(-3)), higher frequency of guttate psoriasis (p < 1 x 10(-9)), more affected legs and trunk (p < 1 x 10(-5)), higher incidence of Köbner's phenomenon (p=0.005) and of trauma history (p=0.009). Cw*0602-negative patients (n= 334) had more palmoplantar pustulosis (p=0.004), nail changes (p=0.001) and scalp involvement (p=0.007). However, there was no statistically significant difference between the two groups regarding age, gender, incidence of plaque psoriasis, erythrodermic, inverse, psoriatic arthritis, and the precipitation factors stress and infection. The study showed that Cw*0602-positive patients had some obvious clinical differences from Cw*0602-negative patients in a Han Chinese population, which provides evidence for an HLA-Cw*0602-associated phenotype in psoriasis.

The problem of pollution caused by highly toxic ions has become the focus of global attention and has attracted the interest of many researchers. However, microdetection using a metal–organic framework remains a challenge. Here, we synthesized the Bi-polycarboxylate organic framework (Bi-MOF) compound [Bi­(BTC)­(H2O)]·H2O constructed by 1,3,5-benzenetricarboxylic acid. Structural analysis revealed that in our Bi-MOF structural unit, the adjacent codimers {Bi2O18} are further joined by C atoms in the H3BTC to form a three-dimensional organic framework. On the basis of the luminescent properties of this Bi-MOF, it could be used as a multifunctional test chemical sensor such as Fe3+ and Cr2O7 2–. In particular, it is found that Bi-MOF has also extremely high selectivity, sensitivity, and uniqueness for Fe3+ and Cr2O7 2–. When the Fe3+ concentration was 0.01 mol/L, the K sv was 2.02 × 104 M–1, and the detection limit was 1.59 μM. When the concentration of Cr2O7 2– was 0.01 mol/L, the K sv was 1.95 × 104 M–1, and the detection limit of Bi-MOF was calculated to be 1.64 μM. This was experimentally verified by analyzing the fluorescence spectrum and fluorescence lifetime. In addition, in a breakthrough of the traditional method of superimposing the three primary colors, we encapsulate Eu3+ in the blue emission center to obtain white light emission by the two primary colors first. This approach can reduce the number of variables that are difficult to control. Therefore, white light emission can be achieved by rationally doping different molar ratios of Eu3+.

Three new metal−organic frameworks (MOFs), n a m e l y , [ P b 7 ( T T P 3), were synthesized by the H 3 TTPCA ligand [H 3 TTPCA = 1,1′,1″-(1,3,5-triazine-2,4,6-triyl)tripiperidine-4-carboxylic acid], with lead(II) nitrate under solvothermal conditions. They were characterized by CHN analysis, IR spectroscopy, UV−vis spectroscopy, and single-crystal and powder X-ray diffraction. In addition, their thermogravimetric analysis and fluorescence properties were studied. Compounds 1− 3 were 3D MOF structures with different Pb x (COO) y clusters: ([Pb 7 (COO) 12 Cl 2 ]), ([Pb 7 (COO) 12 ]), and [Pb 8 (COO) 18 ]. Fluorescence detection of compounds 1−3 shows that they can act as excellent sensors of nitrophenols with a low limit of detection and a high quenching constant.

A series of novel metal–organic frameworks were synthesized by using semirigid ligand 1,1′,1″-(1,3,5-triazine-2,4,6-triyl)­tripiperidine-4-carboxylic acid (H3TTPCA) and lead halide (Cl, Br, or I). The three complexes were characterized by elemental analysis, infrared spectroscopy, ultraviolet–visible spectroscopy, powder X-ray diffraction analysis, and thermogravimetric analysis. X-ray single-crystal diffraction analysis demonstrated that all three complexes were three-dimensional inorganic–organic framework structures with Pb-X2 (X = Cl, Br, or I). However, slight differences in the chemical environment were the focus of the coordinated halogen atoms and the different compositions of metal oxygen clusters: [Pb7(COO)12Cl2], [Pb7(COO)12Br2], and [Pb7(COO)12I2]. Because of the fluorescence of the organic ligand, the three complexes showed similar photoluminescence properties at room temperature, but the intensity of emissions decreased gradually with an increase in the atomic radius of coordinated halogen atoms. Interestingly, in the fluorescence response tests, complexes 1 and 2 displayed an optical signal of fluorescence “turn-on” while complex 3 showed an optical signal of fluorescence “turn-off”. Here we aim to provide a possible mechanism to explain these unique and contradictory luminescence results.