Antibacterial polypeptides as ancient immune defense systems are effective against bacteria. Here we report a novel kind of “armed” carrier: an antibacterial polypeptide-grafted chitosan-based nanocapsule with an excellent antibacterial efficacy against both Gram-positive and Gram-negative bacteria. This nanocapsule also has excellent blood compatibility and low cytotoxicity. Patients after tumor surgery may benefit from this “armed” carrier because it is highly anti-inflammation and is able to deliver anticancer and antiepileptic drugs simultaneously.

We report an unusual homopolymer vesicle, which has a soft bilayer membrane composed of oligo(ethyleneoxy) side chains (OEs) with a gradually decreased packing density from the centre of the membrane to both margins, exhibiting thermo-responsive zeta potential and dispersibility and showing potential applications for anti-cancer drug delivery.

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