Avian flu also known as bird flu is caused by deadly virus H5N1 which initially was found in birds and wild animals, however, later it was found in human beings causing severe respiratory related problems. This review article was performed to understand the epidemiology of outbreaks of H5N1 in different districts of Nepal. First outbreak of strain H5N1 was reported in 2009. Consequently, highest number of outbreaks i.e. 201 was noted in the year 2013. Till date only one human case was identified by NPHL which was later confirmed by genetic laboratory in Japan in collaborating with WHO.

Dear Editor, Rising and remerging pathogens are worldwide difficulties for open health.1 Coronaviruses are wrapped RNA infections that are dispersed extensively among people, different warm-blooded creatures, and flying creatures and that cause respiratory, enteric, hepatic, and neurologic diseases.2, 3 Six coronavirus species are known to cause human illness like 229E, OC43, NL63, and HKU1, SARS – CoV and MERS – CoV.4 Given the high predominance and wide circulation of coronaviruses, the huge hereditary decent variety and successive recombination of their genomes, and expanding human–creature interface exercises, novel coronaviruses are probably going to develop intermittently in people attributable to visit cross-species contaminations and incidental overflow events.5, 6 On January 30, World Health Organization (WHO) pronounced the ebb and flow flare-up that began in Wuhan, China as a Public Health Emergency of International Concern, while prescribing against movement or exchange interruptions to and from China.7 The progressing pandemic of coronavirus ailment 2019 (COVID-19) is brought about by extreme intense respiratory disorder coronavirus 2 (SARS-CoV-2).8 As of 12 April 2020, in excess of 1,777,515 instances of COVID-19 have been accounted for in more than 200 nations and regions, bringing about in excess of 108,862 passings.

Background: Over the recent year there has been a startling rise in the number of people suffering from diabetes mellitus. Estimation of blood glucose levels has been an essential laboratory investigation for screening and monitoring of diabetes. Saliva is one of the secretions in human body whose collection is easy and non-invasive. Salivary glucose hence could serve as an easy and non-invasive tool.Methods: Institutional review committee of NHRC gave us permission to carry out this study. 105 subjects with Type 2 diabetes mellitus who attended the OPD at Star hospital, Sanepa, Lalitpur, Nepal and 106 healthy individuals were consented to participate in this study. Glucose was measured by the GOD-POD (Glucose oxidase peroxidase) methods using the semi-autoanalyser and salivary glucose was compared with corresponding blood glucose levels.Results: A significant positive correlation of fasting salivary glucose level and fasting blood glucose level was observed in healthy (r=0.241, p=0.001) and in diabetic patients (r=0.202, p=0.001).Conclusions: The study implies a potential for saliva in monitoring and screening of diabetes mellitus.

Dengue is a mosquito-borne viral infection with many clinically diverse spectrums of presentations. Although most of the cases are diagnosed clinically, even a simple full blood count (FBC) can assist to confirming this often deceiving infection, which allows the initiation of potentially lifesaving treatment. In this article, two cases of dengue are mentioned, one of which has a high hematocrit and hemoglobin value, which can lead to multiple organ failure and disseminated intravascular coagulation (DIC) and another one added with several atypical clinical manifestation. Thrombocytopenia and leukopenia with positive dengue-NS1 antigen were seen in both cases. Both cases were treated with supportive care and intravenous fluid to improve symptoms. With such complications, there is a need to further examine these cases further in detail.

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