The [2+2+2] cycloaddition strategy is complementary to the well known Diels-Alder reaction for the generation of polycyclic compounds. This [2+2+2] approach is atom-economical and, with the availability of new catalysts to effect the [2+2+2] cycloaddition reaction, synthesis of a wide variety of highly functionalized polycycles is possible. This review deals with some recent advances relating to [2+2+2] cycloaddition reactions involving the syntheses both of polycycles
The design and synthesis of spirocycles is a challenging task because it involves the creation of a quaternary center, which itself is considered to be one of the most difficult tasks among synthetic transformations. Some recent approaches based on metathesis, cycloaddition and transition-metal-mediated transformations to spirocycles are described here.
The most stable is not necessarily the most easy to obtain! Two new stable crystal forms of the 120 year old compound sym‐trinitrobenzene are reported. These elusive forms have been obtained by the use of an additive, trisindane, that can act as a mimic in the crystallization experiment (see scheme).
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