Mindfulness-based meditation has been reported to produce positive effects on psychological and physiological well-being, and to reduce stress levels. The present study examined the effects of a 16-week mindfulness-based stress reduction (MBSR) program on stress levels and self-compassion of 22 executives of a large public sector oil company located in the south of India. The study was a pre-and post-test experimental design in which participants were tested for physiological and psychological parameters, both before and after the intervention. Physiological assessment was carried out through the testing of blood cortisol and measurement of systolic and diastolic blood pressure. Participants also reported on variables such as self-compassion, and various stress indicators such as physical indicators, sleep indicators, behavioral indicators, emotional indicators, and personal habits. Results from the present study suggest that a 16-week MBSR intervention not only had a positive impact on various stress indicators (physical, sleep, behavioral, emotional, and personal habits) and self-compassion but also reduced systolic and diastolic blood pressure and blood cortisol levels. The findings suggest that MBSR can be a useful stress management intervention for addressing the issues of high stress for senior executives in Indian organizations.