No abstract

Introduction:The endometrial function and endometrial receptivity have been accepted to be major limiting factors in the establishment of pregnancy. In spite of improved almost all aspects of IVF: ovarian stimulation, embryo culture and transfer, the pregnancy rates still not satisfactory. The bottleneck is the process of implantation. Recurrent implantation failure (RIF) is one of the nightmares in reproductive medicine and despite several strategies that have been described for management; there is no universal agreement yet. Recently, intrauterine infusion of platelet-rich plasma (PRP) is described to promote endometrial growth and receptivity, PRP has been investigated as a therapeutic approach for several medical disorders in dermatology and rheumatology, but its use in IVF is still limited. Aim: To evaluate the effectiveness of intrauterine perfusion of autologous platelet-rich plasma in improvement of pregnancy rate in RIF patients. Design: Prospective randomized controlled study. Patients and Methods: After ethical committee approval was obtained, 150 infertile women with history of RIF gave their consent to be included in this study, with age below 40 yrs, body mass index (BMI) below 30 kg/m2. They were divided into 2 comparable groups ; all participants underwent antagonist protocol. In the study group, intrauterine infusion of (PRP) was performed 48 hrs before blastocyst transfer, pregnancy tests were done 12 days after ET. Results: Out of 75 participants in each group, 32 got pregnant (43%) in the study group, compared to 11 pregnant participants (15%) in control group. Conclusion: According to our study, PRP significantly improved the pregnancy rate and may be a new hope in RIF patients.

No abstract

No abstract

Research question: Precise timed synchronization between endometrium and the embryo is essential for high implantation and pregnancy rate, it is worthy to mention that endometrial thickness is not the only factor, E2 and P levels are also regularly monitored for endometrial receptivity. So, we decided to go for this study, to investigate the impact of serum E2 and P levels on the same day of embryo transfer on pregnancy outcomes for FET cycles. Design: This was a retrospective cross sectional study for 402 FET cycles which conducted between April 2018 and May 2019. All participants started endometrial preparation for FET with 6 mg/day oral estradiol for 13 days. When endometrium reached 8 mm or greater, patients were initiated on both micronized vaginal and oral P treatment. On FET day, serum level of E2 and P were assessed. Then, transfer of PGT euploid embryos was performed. 12 days later pregnancy test was assessed, and then 4 weeks after FET date ultrasound was scheduled to check the viability and the clinical pregnancy. Results: The mean E2 value was 931.41 ± 438.65 pg/ml, while mean P value was 8.47 ± 9.4 ng/ml. 240 out of 402 cases got pregnant (59.7%) while the clinical pregnancy rate was 53.9% with no correlation between serum (E2, P & E/P ratio) and the outcome. Conclusion: Our results revealed that the association between E2 and P on FET day and the pregnancy outcome is still not proven and those markers can't serve as predictors for the outcome. Research question:Precise timed synchronization between endometrium and the embryo is essential for high implantation and pregnancy rate, it is worthy to mention that endometrial thickness is not the only factor, E2 and P levels are also regularly monitored for endometrial receptivity. So, we decided to go for this study, to investigate the impact of serum E2 and P levels on the same day of embryo transfer on pregnancy outcomes for FET cycles.