Purpose of the Study: Explore the role of MRI in the diagnosis of Charcot foot in patients with early-stage diabetic osteoarthropathy. Material and Methods Research: 45 patients (prospectively) with type 2 diabetes and Charcot's foot were examined in the period 2021-2022 at the RSNPMC of Endocrinology named after Academician Y.Kh. Turakulova, in the department of diabetic foot. All observed patients were divided into 2 groups:

Purpose of the Study: explore biochemical characteristics of patients with severe complications of diabetic foot syndrome (ulcer, gangrene, amputation) associated with chronic kidney disease. ResearchMaterial: We examined 91 patients (prospectively) with type 2 diabetes with severe complications in the period 2021-2024 at the RSSPMC of Endocrinology, in the department of diabetic foot. All observed patients were divided into 4 groups: a) 1 gr. -25 patients with DFS complicated by ulcer, gangrene and amputation and in combination with CKD 4-5 stages on hemodialysis b) 2 gr. -25 patients with DFS complicated by ulcer, gangrene and amputation in combination with CKD stages 4-5 without hemodialysis c) 3 gr -20 patients with DFS complicated by gangrene and amputation without CKD. d) 4 gr -21 patients with DFS, without severe complications, with the initial stage of CKD.The control group consisted of 20 healthy individuals.Research Methods: Biochemical (bilirubin, direct, indirect, lipid spectrum, ALT, AST, PTI, coagulogram, blood sugar, glycated hemoglobin, urea, creatinine, GFR, wound pathogens, procalcitonin, interleukin-6, vascular endothelial growth factorVEGF-A and instrumental: ECG, MRI of the feet, Diplography of the main vessels of the legs, ultrasound of the internal organs, the fundus. Research Results:The highest rates of fasting glycemia were observed in patients of group 2, that is, with DFS and CKD 4-5 stages without hemodialysis. Significantly lower hemoglobin values were also observed in this group of patients (p<0.001), glycated hemoglobin significantly higher values of urea, creatinine and GFR (p<0.001). All patients had significantly reduced values of HDL (p<0.001) and total cholesterol (p<0.05). Conclusion:Biochemical parameters were significantly impaired in patients of group 1, that is, with DFS and CKD 4-5 stages on hemodialysis, which indicates the need for further research in this group of patients.

The purpose of the study is to study the correlation rate of the quality of life, electroneuromyography, doppler and neuro markers BNDF in the blood in patients with a type 2 of type with diabetic foot syndrome. Methods: The following 2 groups of patients were formed: 1 gr. - SDS patients, neuropathic form -37 patients, 2 gr. - SDS patients, neuroichmic form -35 patients, 3 gr. - Control group, these are 20 healthy persons of the appropriate age and gender. Results: In all groups of patients, the quality of life is significantly different in the FSHC questionnaire compared with the control group (p <0.05). In patients with a neuroecemic form of diabetic foot syndrome, a significant decrease was found (p <0.05). All indicators of doppler song vessels of legs compared with patients with neuropathic shape. Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia of an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the lower leg, is discovered. The definition of neuromuscular transmission showed that the patients of the 1st and 2nd groups have a weak reduction in muscle contraction involuntarily. This confirmed the impairment of neuromuscular transmission in both groups. Conclusions: 1) A questionnaire to determine the quality indicators - FSHK is the most sensitive and informative to determine the quality of life in patients with type 2 diabetes mellitus with neuropathic and neuroecemic forms 2) FSHP questionnaire can be used for dynamic assessment of type 2 diabetes patients with neuropathic and neuroecemic forms in outpatient clinical practice. 3) Revealed significant correlations of FSHK and laboratory and instrumental indicators. A correlation connection with the duration of the disease, the duration of the disease, the levels of glycemia on an empty stomach, the level of the glycated haemoglobin, BNDF in the blood, the speed of blood flow in the femoral artery, in the shin, M-answer when stimulating a tibial nerve.

Annotation: In this article, the authors presented the results of a review of the literature on one of the terrible complications of type 2 diabetes - diabetic foot syndrome in the stage of severe complications (ulcer, gangrene, amputation) associated with chronic kidney disease. This topic, despite its relevance, is still poorly understood. As a result of the analysis of the literature, the authors come to the conclusion that after the start of renal replacement therapy in patients on hemodialysis, there is an increase in the incidence of the neuro-ischemic form of the diabetic foot syndrome. Along with this, the progression of chronic obliterating diseases of the arteries of the lower extremities during the observation period was noted only among diabetic patients on hemodialysis. Therefore, it is necessary to find ways for early prevention of these complications, early diagnosis and treatment. Keywords: diabetic foot syndrome, diabetic patients, complications, CKD.