Background Well-being is a multidimensional concept and has been extended to many areas. Student well-being has garnered attention over the last decade due to concerns that have been raised. Digital health interventions have the potential to enhance and improve student well-being. Objective The objective of the study is to design, develop, and pilot-test a digital health platform to enhance student well-being. Methods A sample size of 5000 participants will be recruited across Gujarat and Tamil Nadu, India. Students will be enrolled from Parul University in Vadodara, Gujarat, as well as Panimalar Medical College Hospital and Research Institute, Panimalar Engineering College, Panimalar Institute of Technology, and Panimalar College of Nursing in Chennai, Tamil Nadu. Current undergraduate and graduate students consenting to participate will be recruited using convenience sampling from these institutes. The study will collect baseline data to construct the student well-being index. Based on the risk profile, a random subset of the population will be provided access to the digital health intervention, which will deliver tailored interactive messages addressing the various dimensions of well-being among undergraduate and graduate students. The eligible study participants will be aged 18 years and older, enrolled in these institutes, and willing to give their consent to participate in the study. Results The proposed research is an unfunded study. The enrollment of the individuals in the study began in October 2022. Data gathered will be analyzed using SAS (version 9.3; SAS Institute) and results will be reported as 95% CIs and P values. Conclusions The proposed study will help to determine the factors affecting well-being among college students and help in designing digital health interventions to improve the well-being of undergraduate and graduate students. International Registered Report Identifier (IRRID) PRR1-10.2196/39779

BACKGROUND Well-being is a multidimensional concept and has been extended to many areas. Student well-being has garnered attention over the last decade due to increased well-being issues. Digital health interventions have the potential to enhance and improve student well–being. OBJECTIVE The study aims to identify the multiple determinants impacting dimensions of well-being among undergraduate and graduate students. It further aims to design and develop an interactive digital intervention for various dimensions of well-being. The study will also evaluate the feasibility and acceptance of digital health intervention and their role to enhance the well-being of undergraduate and graduate students. METHODS 5000 thousand participants will be recruited across Gujarat and Tamil Nadu, India. These participants will be enrolled from, Parul University, Vadodara, Gujarat, Panimalar Medical College Hospital, and Research Institute, (PMCHRI), and Panimalar college of nursing Chennai, Tamil Nadu. Current undergraduate and graduate students agreeing to participate will be recruited using convenience sampling from these two institutes. The study will collect baseline data to construct the student well-being index. A random subset of the population will be provided access to the digital platform that will deliver tailored interactive messages addressing the various dimensions of well-being among undergraduate and graduate students. The eligible study participants will be of 18 years and older, enrolled in these institutes, and willing to give their consent to participate in the study. Subjects will be excluded if they are less than 18 years of age, and not willing to give consent. RESULTS The study will help to identify the factors affecting well-being among college students. The findings of this study will help to design, develop, implement and evaluate tailored internet-based, interactive, digital health interventions to enhance student well-being. The study will also evaluate the feasibility and acceptance of digital health intervention and help in understanding their role to enhance student well-being. All statistical analysis will be performed using SAS v9.3 and results will be reported as 95% CI and P-values. CONCLUSIONS The proposed study will help to determine the factors affecting well-being among college students and also help in designing digital health interventions to improve the well-being of the undergraduate and graduate students