Uterine myomas are a real handicap for women in Africa. The aim of this study was to determine the clinical, psychological and socio-professional impact of symptomatic uterine myomas.We conducted a descriptive cross-sectional study from December 2017 to May 2018 in the gynecology department of the Yaoundé Gyneco -Obstetrics and Pediatric Hospital.We included 101 women aged on average 38.7 +/-7.6 years, living in urban areas. Female genital bleeding was found in 63.3% of women, anemia in 95%, women and infertility in 57% of women.Moderate anxiety accounted for 46.5% of patients, mental depression 70.3%, social discomfort with a negative effect on the couple in 32.7%, absenteeism at work in 70.3%, decrease in work efficiency, 64.4% of the patients.Uterine myomas have a clinical effect (bleeding and infertility), a psychological impact (anxiety, depression) and socio professional impact (decreased work efficiency and absenteeism at work) in women.