It is suggested that in gold nanoparticles (GNPs) of about 5 nm sizes used in the radiofrequency (RF) hyperthermia, an absorption of the RF photon by the Fermi electron occurs with involvement of the longitudinal acoustic vibrational mode (LAVM), the dominating one in the distribution of vibrational density of states (VDOS). This physical mechanism helps to explain two observed phenomena: the size dependence of the heating rate (HR) in GNPs and reduced heat production in aggregated GNPs. The argumentation proceeds within the one-electron approximation, taking into account the discretenesses of energies and momenta of both electrons and LAVMs. The heating of GNPs is thought to consist of two consecutive processes: first, the Fermi electron absorbs simultaneously the RF photon and the LAVM available in the GNP; hereafter the excited electron gets relaxed within the GNP's boundary, exciting a LAVM with the energy higher than that of the previously absorbed LAVM. GNPs containing the Ta and/or Fe impurities are proposed for the RF hyperthermia as promising heaters with enhanced HRs, and GNPs with rare-earth impurity atoms are also brought into consideration. It is shown why the maximum HR values should be expected in GNPs with about 5 − 7 nm size.The authors dedicate this work to the 90th anniversary of professor Leonid V. Tuzov

Summary Background: The need for practical and adaptable terahertz sources is apparent in the areas of application such as early cancer diagnostics, nondestructive inspection of pharmaceutical tablets, visualization of concealed objects. We outline the operation principle and suggest the design of a simple appliance for generating terahertz radiation by a system of nanoobjects – gold nanobars (GNBs) or nanorings (GNRs) – irradiated by microwaves. Results: Our estimations confirm a feasibility of the idea that GNBs and GNRs irradiated by microwaves could become terahertz emitters with photon energies within the full width at half maximum of the longitudinal acoustic phononic DOS of gold (ca. 16–19 meV, i.e., 3.9–4.6 THz). A scheme of the terahertz radiation source is suggested based on the domestic microwave oven irradiating a substrate with multiple deposited GNBs or GNRs. Conclusion: The size of a nanoobject for optimal conversion is estimated to be approx. 3 nm (thickness) by approx. 100 nm (length of GNB, or along the GNR). This detailed prediction is open to experimental verification. An impact is expected onto further studies of interplay between atomic vibrations and electromagnetic waves in nanoobjects.

A technique is suggested (that includes the device's scheme and assessments of its feasibility) for imaging cancer cells in biological tissue samples in vitro and in human skin in vivo, exposing them to 4.2 THz radiation and using a THz-to-infrared (IR) converter in combination with an IR sensitive camera. The converter includes a system of gold nanoparticles embedded into a substance transparent in THz and IR, e.g., Teflon ®. The heat exchange between gold nanoparticles and their embedding substance is simulated in a calculation. The convenient size of nanoparticles and their concentration in the substrate are estimated. ! 1

The design is suggested, and possible operation parameters are discussed, of an instrument to inspect a skin cancer tumour in the terahertz (THz) range, transferring the image into the infrared (IR) and making it visible with the help of standard IR camera. The central element of the device is the THz-to-IR converter, a Teflon R or silicon film matrix with embedded 8.5 nm diameter gold nanoparticles. The use of external THz source for irradiating the biological tissue sample is presumed. The converter's temporal characteristics enable its performance in a real-time scale. The details of design suited for the operation in transmission mode (in vitro) or on the human skin in reflection mode (in vivo) are specified.(To be pubished in the proceedings of the FANEM-

Gold nanoparticles (GNPs) may serve as devices to emit electromagnetic radiation in the terahertz (THz) range, whereby the energy is delivered by radio frequency or microwave photons which will not by themselves induce transitions between sparse confinement-shaped electron levels of a GNP, but may borrow the energy from longitudinal acoustic (LA) phonons to overcome the confinement gap. Upon excitation, the Fermi electron cannot relax otherwise than via emitting a THz photon, the other relaxation channels being blocked by force of shape and size considerations. Within this general scope that has already been outlined earlier, the present work specifically discusses two-phonon processes, namely (i) a combined absorption-emission of two phonons from the top of the LA branch, and (ii) an absorption of two such phonons with nearly identical wavevectors. The case (i) may serve as a source of soft THz radiation (at ≃0.54 THz), the case (ii) the hard THz radiation at 8.7 THz. Numerical estimates are done for crystalline particles in the shape of rhombicuboctahedra, of 5-7 nm size. A technical realisation of this idea is briefly discussed, assuming the deposition of GNPs onto/within the substrate of Teflon, the material sustaining high temperatures and transparent in the THz range.