The ability to recognise the identity of others is a key requirement for successful communication. Brain regions that respond selectively to voices exist in humans from early infancy on. Currently, it is unclear whether dysfunction of these voice-sensitive regions can explain voice identity recognition impairments. Here, we used two independent functional magnetic resonance imaging studies to investigate voice processing in a population that has been reported to have no voice-sensitive regions: autism spectrum disorder (ASD). Our results refute the earlier report that individuals with ASD have no responses in voice-sensitive regions: Passive listening to vocal, compared to non-vocal, sounds elicited typical responses in voice-sensitive regions in the high-functioning ASD group and controls. In contrast, the ASD group had a dysfunction in voice-sensitive regions during voice identity but not speech recognition in the right posterior superior temporal sulcus/gyrus (STS/STG)—a region implicated in processing complex spectrotemporal voice features and unfamiliar voices. The right anterior STS/STG correlated with voice identity recognition performance in controls but not in the ASD group. The findings suggest that right STS/STG dysfunction is critical for explaining voice recognition impairments in high-functioning ASD and show that ASD is not characterised by a general lack of voice-sensitive responses.

Eye contact occurs frequently and voluntarily during face-to-face verbal communication. However, the neural mechanisms underlying eye contact when it is accompanied by spoken language remain unexplored to date. Here we used a novel approach, fixation-based event-related functional magnetic resonance imaging (fMRI), to simulate the listener making eye contact with a speaker during verbal communication. Participants’ eye movements and fMRI data were recorded simultaneously while they were freely viewing a pre-recorded speaker talking. The eye tracking data were then used to define events for the fMRI analyses. The results showed that eye contact in contrast to mouth fixation involved visual cortical areas (cuneus, calcarine sulcus), brain regions related to theory of mind/intentionality processing (temporoparietal junction, posterior superior temporal sulcus, medial prefrontal cortex) and the dorsolateral prefrontal cortex. In addition, increased effective connectivity was found between these regions for eye contact in contrast to mouth fixations. The results provide first evidence for neural mechanisms underlying eye contact when watching and listening to another person talking. The network we found might be well suited for processing the intentions of communication partners during eye contact in verbal communication.

Speech information inherent in face movements is important for understanding what is said in face-to-face communication. Individuals with autism spectrum disorders (ASD) have difficulties in extracting speech information from face movements, a process called visual-speech recognition. Currently, it is unknown what dysfunctional brain regions or networks underlie the visual-speech recognition deficit in ASD.We conducted a functional magnetic resonance imaging (fMRI) study with concurrent eye tracking to investigate visual-speech recognition in adults diagnosed with high-functioning autism and pairwise matched typically developed controls.Compared to the control group (n = 17), the ASD group (n = 17) showed decreased Blood Oxygenation Level Dependent (BOLD) response during visual-speech recognition in the right visual area 5 (V5/MT) and left temporal visual speech area (TVSA) – brain regions implicated in visual-movement perception. The right V5/MT showed positive correlation with visual-speech task performance in the ASD group, but not in the control group. Psychophysiological interaction analysis (PPI) revealed that functional connectivity between the left TVSA and the bilateral V5/MT and between the right V5/MT and the left IFG was lower in the ASD than in the control group. In contrast, responses in other speech-motor regions and their connectivity were on the neurotypical level.Reduced responses and network connectivity of the visual-movement regions in conjunction with intact speech-related mechanisms indicate that perceptual mechanisms might be at the core of the visual-speech recognition deficit in ASD. Communication deficits in ASD might at least partly stem from atypical sensory processing and not higher-order cognitive processing of socially relevant information.