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Objective: Masked hypertension is a clinical condition, the importance of which is agreed in recent years and which is characterized by increased cardiovascular mortality and morbidity and is thought to be important endothelial dysfunction in the pathophysiology. Plasma total homocysteine levels are accepted as a major independent biomarker for endothelial dysfunction and/or a contributor to hypertension and coronary artery disease. In this study, we aimed to measure the level of serum homocysteine and to evaluate the relationship between the parameters of ambulatory blood pressure monitoring in patients with masked hypertension. Methods: This cross-sectional observational study included 37 subjects with normal blood pressure, 30 with masked-hypertension and 27 patients with obvious hypertension. Masked hypertension (MHT) was defined as office blood pressure <140/90 mm Hg and mean daytime ambulatory systolic blood pressure in 24 hours monitoring ≥135/85 mm Hg. Homocysteine levels of the subjects were measured by using HPLC system with fluorescent detector. Lipid parameters were measured by routine methods. Mann-Whitney U test was used for statistical analysis. Results: In the analysis of homocysteine, it was observed that there was no difference between the control group and patients with MHT. Patients with high blood pressure showed higher homocysteine levels when compared to MHT (p=0.02). Homocysteine levels showed a weak positive correlation with average systolic blood pressure (r=0.335, p=0.043). Homocysteine levels were higher in smokers than non-smokers. compared with non-smokers group in all participants (p=0.036). Conclusion: We have reached the opinion that in the individuals with no obvious health problems but with MHT, homocysteine levels may not have any significant effect upon high blood pressure levels. (Anadolu Kardiyol Derg 2014; 14: 357-62)

Objectives In this study, it was aimed to evaluate the hypoxia-inducible factor-1α (HIF-1α) and ischemia-modified albumin (IMA) levels of patients diagnosed with COVID-19 in the intensive care unit (ICU) and healthy controls. To our knowledge, this is the first study investigate HIF-1α and IMA levels in COVID-19 patients in ICUs and comparing them with a healthy control group. For this reason, our study is original and will contribute to the literature. Methods A total of 70 intensive care patients diagnosed with COVID-19, and 72 healthy controls were included in the study. Results When we compared the patient and healthy control group; there were no statistically significant differences between the groups in terms of age and gender (p>0.05). No exitus was observed in the patient group. We found weak correlation between HIF-1α and IMA (r: 0.320). However, there were statistically significant differences in HIF-1α and IMA levels in the patient group. The receiver operating characteristic (ROC) curve demonstrated an area under curve (AUC) value of 0.651 for HIF-1α and 0.937 for IMA. Conclusions The HIF-1α and IMA levels were significantly higher among COVID-19 patients in ICU compared with healthy controls. HIF-1α and IMA levels can be used as reliable markers for the prognosis of COVID-19.

Objectives: In this study, nutritional habits of students, knowledge attitudes and behaviors about healthy nutrition will be evaluated. Materials and Methods:The sample comprised 818 students enrolled in the departments of the School of Health Sciences and the bachelor's programs offered by the Faculty of Medicine. The developed data collection form consists of 52 questions.Results: In this study 818 (665 female, 153 male) students were reached. 22.3% of the students stated that smoke and 10.2% stated that used alcohol. The nutritional knowledge level was significantly higher in non-smokers, those that did not consume alcohol, those with a family history of diabetes mellitus, hypertension or coronary disease, those that exercised ≥6 hours a week, those that had knowledge of and consumed probiotic products, and those that had >3 meals/day (p=0.019, p=0.001, p=0.048, p=0.006, p=0.032, p=0.046, p=0.000, p=0.000, p=0.001, respectively). There was no significant relationship between the participants' level of nutritional knowledge and the educational level of their parents, monthly net income, type of accommodation, BMI, whether they had previously received nutritional education, skipping meals, consumption of milk, egg, bread or water, sleep duration, and constipation (p=0.88, p=0.069, p=0.055, p=0.070, p=0.072, p=0.0671, p=0.244, p=0.425, p=0.494, p=0.177, p=0.186, p=0.088, respectively). Conclusion:Students should be educated about converting their knowledge about healthy nutrition into attitudes and behaviors, and their knowledge should be increased with courses and various activities related to healthy nutrition.