Aim: To evaluate the antihyperlipidemic activity of leaves of cassia tora Objective: Hyperlipidemia is a clinical condition causing lethal diseases like atherosclerosis, myocardial infarction etc that ultimately leads to death. Several works have been reported that the extracts of many plants have antihyperlipidemic activity. Cassia tora is used for a long time as a daily vegetable in many countries. It consists of phytochemical constituents like flavonoids which lowers blood cholesterol level. Materials and Methods: Materials used: Antihyperlipidemic activity of Cassia tora was screened by a model, Cholesterol diet induced hyperlipidemia. Marker enzymes like LDH, LDL, VLDL, total protein, total cholesterol, AST, ALP, ALT,SOD, Catalase, LPO and histopathology of myocardium and aorta carried out. Results: Flavonoids of leaves of Cassia tora treated group showed significant decrease in LDL-Cholesterol, total cholesterol, triglycerides, AST, ALT, ALP and increase in HDL cholesterol, albumin, total protein and further was concluded by histopathological studies. Conclusion: From result, it was concluded that flavonoid of leaves of Cassia tora shows antihyperlipidemic activity in the heart of rats.