To reveal the effect of tip clearance on the flow behaviors and pressurization performance of a helico-axial flow pump, the standard k-ε turbulence model is employed to simulate the flow characteristics in the self-developed helico-axial flow pump. The pressure, streamlines and turbulent kinetic energy in a helico-axial flow pump are analyzed. Results show that the tip leakage flow (TLF) forms a tip-separation vortex (TSV) when it enters the tip clearance and forms a tip-leakage vortex (TLV) when it leaves the tip clearance. As the blade tip clearance increases, the TLV moves along the blade from the leading edge (LE) to trailing edge (TE). At the same time, the entrainment between the TLV and the main flow deteriorates the flow pattern in the pump and causes great hydraulic loss. In addition, the existence of tip clearance also increases the possibility of TLV cavitation and has a great effect on the pressurization performance of the helico-axial flow pump. The research results provide the theoretical basis for the structural optimization design of the helico-axial flow pump.