1. We investigated the effect of intermittent exposure to hypobaric hypoxia on the ability of neutrophils to generate.O2-. 2. Seven male volunteers were exposed intermittently to hypobaric hypoxia, equivalent to an altitude of 4500 m, for 7 successive days. Peripheral blood samples were collected before and after the 2 h course of hypobaric hypoxia on days 1 and 7 and neutrophils were subjected to a chemiluminescence assay for.O2- production. 3. On day 1, 2 h exposure to hypobaric hypoxia induced granulocytosis (P < 0.01), but the ability of neutrophils to generate.O2- was unchanged. 4. On day 7, such granulocytosis was not observed, suggesting acclimatization to hypobaric hypoxia. 5. The ability of neutrophils to generate.O2- was significantly increased on day 7 (P < 0.01), although there was no definite change in the mRNA expression of NADPH oxidase subunits in the cells. 6. The results suggest that the ability of neutrophils to generate.O2- may be gradually potentiated by intermittent exposure to hypobaric hypoxia, even after the number of neutrophils in peripheral blood stabilizes.
Participants in this study had an increased ratio of silent brain infarction compared with Japanese healthy controls, accompanied with higher ratios of diabetes and low HDL cholesterol.
Purpose: To retrospectively determine the effectiveness of percutaneous vertebroplasty (PVP) for patients with ambulation difficulties due to acute osteoporotic vertebral fractures.Materials and Methods: We enrolled 62 patients who met the following criteria: almost normal ambulation before osteoporotic vertebral fracture, ambulation difficulties after onset, and a first-time PVP performed within 4 weeks. The patients were divided into Earlier (n = 46) or Later groups (n = 16) in which patients underwent PVP within 2 weeks or later, respectively. Mobility scores 7 days post-PVP in the Earlier group were compared with those 1 day before PVP in the Later group, that is, the conservatively waiting state. Earlier group values were also compared with those at 7 days post-PVP in the Later group to estimate the effectiveness of later PVP.Results: Mobility scores at 7 days post-PVP in Earlier group were significantly better than those 1 day before PVP in the Later group, suggesting that PVP provided mobility improvements sooner than the conservatively waiting state. Meanwhile, the lack of a difference in mobility scores at 7 days post-PVP between the Earlier and Later groups indicated that later PVP provided improvement comparable to earlier PVP.Conclusion: Earlier PVP contributes to earlier recovery from ambulation difficulties due to acute osteoporotic vertebral fractures than later PVP, while earlier and later PVP show equivalent efficacy in restoration of ambulation.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.