Brønsted acid-promoted intramolecular hydroarylation of alkynylbenzenes carrying an arylalkyl group at the ortho-position leads to alkylidenedibenzo[a,d]cycloheptenes, -octenes and -nonenes in up to quantitative yield with complete regioselectivity. The scope and limitation of this reaction and application to the synthesis of tricyclic antidepressants are described.

The synthesis and structural analyses of pincer-type iridium complexes having gallyl- and indyl-metalloligands were achieved utilizing 2,5-bis(6-phosphino-2-pyridyl)pyrrolide as a new scaffold for metal–metal bonds.

The metabolic syndrome caused by visceral-fat obesity is a major risk factor for atherosclerosis. This study used a new information communication technology (ICT) to investigate body weight (BW) and blood pressure (BP) changes in response to nutritional guidance. Obese subjects with hypertension, hyperlipidemia, or impaired glucose tolerance received guidance with the ICT method (n = 13) or face-to-face according to conventional methods (n = 39). The effects of the methods were compared. After 12 weeks, significant weight loss and BP reduction were observed in the ICT group. Also, significant higher improvements were observed in total cholesterol (TC), low-density lipoprotein (LDL) cholesterol, and HbA(1c) in the ICT-group compared with those groups using the conventional method. The effectiveness of the ICT method in reducing BW, BP, total and LDL cholesterol, and HbA(1c) was demonstrated.

Construction of Dibenzo-Fused Seven-to Nine-Membered Carbocycles via Broensted Acid-Promoted Intramolecular Friedel-Crafts-TypeAlkenylation. -(OTANI*, T.; UEKI, K.; CHO, K.; KANAI, K.; TATENO, K.; SAITO, T.; Chem. Commun. (Cambridge) 51 (2015) 37, 7895-7898, http://dx.