Aim: The present study aims to evaluate the impact strength of PMMA incorporated with TiO 2 nanoparticles by two different processing techniques i.e. water bath and microwave processing techniques. Materials and methods: A total of 80 samples made of PMMA were divided into four groups. Each group includes 20 samples with group I and II comprising of samples made of normal acrylic resin and acrylic resin reinforced with 1 wt% TiO 2 nanoparticles processed with conventional water bath technique respectively, groups III and IV include normal acrylic resin and acrylic resin reinforced with 1 wt% TiO 2 processed using microwave technique respectively. The specimens were tested for impact strength using IZOD pendulum impact tester. The impact energy values obtained were analyzed statistically. Results: The results through one-way ANOVA showed a high mean impact strength with group IV samples (23.13) and lowest with respect to group I (19.42) with highest statistical significance (p < 0.001). A post hoc Tukey test intergroup analysis showed a statistically significant difference between group I and other groups, whereas there was no statistical significance associated with other intergroup comparisons. Conclusion: PMMA with its current drawbacks in the physical and mechanical properties requires modifications to make it an ideal denture base material. The current investigation evaluates that a high mean impact strength with samples made of PMMA incorporated with TiO 2 nanoparticles processed by microwave technique was obtained when compared with normal acrylic resins processed by water bath technique. Clinical significance: The methodology of current study can be used while processing of denture bases for patients to evaluate the effect of oral environment on inclusion of TiO 2 nanoparticles with microwave processing in a clinical setup. This could help in reducing the amount of fractures associated with heavy load masticatory stresses and improving the mechanical properties in denture bases.