Silvery hair is a rare clinical manifestation which is a common presentation in a group of rare syndromes which usually present in the pediatric age group together termed as “silvery hair syndrome,” consisting of Chediak-Higashi syndrome (CHS), Griscelli syndrome (GS), and Elejalde disease. CHS is a rare autosomal recessive disorder. It is characterized by mild pigment dilution (partial oculocutaneous albinism), silvery blond hair, severe phagocytic immunodeficiency, bleeding tendencies, recurrent pyogenic infections, progressive sensory or motor neurological defects. GS is also a rare autosomal recessive disorder characterized by reduced skin pigmentation, often regarded as partial albinism and silvery grey hair combined with immunodeficiency. To make correct diagnosis and to differentiate between CHS and GS, it requires light microscopic examination of skin and hair shafts, immunological and peripheral blood smear evaluation. They have been reported to be associated with some common clinical association as a part of the syndrome due to pigmentary delusion, neurological dysfunction, and severe life-threatening infections due to neutrophil phagocytosis dysfunction. There are reports of few rare associations and varied presentations and variable mean survival age. We report two cases with common presentation of silvery hair but varied systemic and clinical manifestations and survival in two cousin brothers from the same family.

Acute toxic effects of several 12,13-epoxytrichothecenes were investigated in 1day-old broiler chicks by single oral doses. The 7-day median lethal dose values of purified 8-acetylneosolaniol, diacetoxyscirpenol, T-2 toxin, HT-2 toxin, neosolaniol, deacetyl-HT-2 toxin, and T-2 tetraol were 3.22 ± 0.26, 3.82 + 0.40, 4.97 +

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Objective: To investigate the anti-arthritic activity of ethanolic extract of Caesalpinia pulcherrima (ECP) in adjuvant arthritic (AA) rat model induced by Freund's complete adjuvant (FCA). Methods: Thirty healthy albino rats were selected and randomly divided into five groups. Arthritis was induced by Freund's complete adjuvant (FCA) and then treated with ethanolic extract of Caesalpinia pulcherrima for 28 days. The various parameters like paw volume, haematological parameters (RBC, WBC, Hb and ESR), and radiological studies were assessed. Results: In FCA induced arthritic rats, there was significant increase in rat paw volume whereas both doses of ECP treated groups showed strong significant reduction in paw volume. The altered haematological parameters in the arthritic rats were significantly recovered to near normal by the treatment with ECP at the dose of 200 and 400 mg/kg. Further radiological studies revealed the anti-arthritic activity of ECP by preventing cartilage and bone destruction of the arthritic joints of AA rats. Conclusion: ECP has shown anti-arthritic activity with a significant decrease in paw volume and it could significantly normalize the haematological abnormalities in adjuvant induced arthritic rats. Further radiological studies confirmed the anti-arthritic activity of ECP.

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